ReviewLife (Basel, Switzerland)2025
The Effects of the Association Between a High-Fat Diet and Physical Exercise on BDNF Expression in the Hippocampus: A Comprehensive Review.
Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Punica granatum L. peel extract mitigates hyperlipidemia-induced cognitive impairments in zebrafish larvae via modulating LXR signaling.Metabolic brain disease · 2026Article
- Neuroprotective impact of nicotinamide riboside and metformin on the hippocampus of male rats with diet-induced obesity.Metabolic brain disease · 2026Article
- Caffeic acid restores neurogenesis and synaptic integrity under glucolipotoxic stress by suppressing inflammation and pyroptosis.Metabolic brain disease · 2026Article
- Article
- Ethanol exposure and high-fat diet: assessing the neuroimmune and metabolic mechanisms in Alzheimer's disease pathology.Frontiers in neuroscience · 2026Review
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- A comment on "Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study".Journal of translational medicine · 2025Article
- Neurotoxic Effects of Bisphenol (BPA): Mini-Reviews.Toxics · 2025Review
- High-Fat Diet Alters Behavior and Hippocampal Gene Expression.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
High-fat diets, characterised by their high lipid content, have been associated with structural and functional alterations in the hippocampus of rodents, including a reduction in the expression of brain-derived neurotrophic factor (BDNF), which negatively impacts learning and memory. Evidence suggests that these impairments may be attenuated by regular physical exercise. This review aimed to gather relevant scientific evidence available on the effects of the association between high-fat diets and physical exercise on BDNF expression levels in the hippocampus of rats. The studies analysed highlight a neuroprotective effect of exercise, capable of positively modulating BDNF levels and, consequently, improving the cognitive functions of these animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.