ArticleLife (Basel, Switzerland)2025
Prognostic Value of Matrix Metalloproteinase 9 (MMP9) in Patients Following Off-Pump Coronary Artery Bypass Grafting.
Mikhail Popov, Siarhei Dabravolski, Vladislav Dontsov, Sergei Vzvarov, Evgeniy Agafonov, Dmitriy Zybin, Olga Radchenkova, Dmitriy Saveliev, Victoria Pronina, Natalia Kashirina and 9 more
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In one paragraphArticle in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
19 authors.
Mikhail PopovM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0000-0002-0316-8410 Siarhei DabravolskiDepartment of Biotechnology Engineering, Braude Academic College of Engineering, Snunit 51, P.O. Box 78, Karmiel 2161002, Israel.ORCID 0000-0002-0547-6310 Vladislav DontsovM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0000-0003-2904-5213 Sergei VzvarovM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0009-0007-2548-7029 Evgeniy AgafonovM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.
Dmitriy ZybinM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.
Olga RadchenkovaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0009-0004-4372-3302 Dmitriy SavelievM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0009-0003-1571-4583 Victoria ProninaM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0000-0002-2348-1500 Natalia KashirinaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, Russia.
Liudmila LipatovaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, Russia.ORCID 0000-0003-0176-5147 Mikhail PekloNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, Russia.
Pavel RutkevichNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, Russia.ORCID 0000-0001-7295-256X Elena YanushevskayaNational Medical Research Center of Cardiology Named After Academician E.I. Chazov, 21552 Moscow, Russia.
Alisa SokolovskayaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, Russia.ORCID 0000-0002-0112-2734 Arkadiy MetelkinInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, Russia.ORCID 0000-0001-8018-4978 Svetlana VerkhovaInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, Russia.ORCID 0000-0002-7953-0586 Nikita NikiforovInstitute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, 125315 Moscow, Russia.ORCID 0000-0002-2082-2429 Dmitriy ShumakovM.F. Vladimirsky Moscow Regional Clinical Research Institute, Schepkina St. 61/2, 129110 Moscow, Russia.ORCID 0000-0003-4204-8865 Funding
Russian Science Foundation 25-25-00348
6 · The paper itselfAbstract
backgroundMatrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases (CVD). However, little is known regarding the significance of elevated plasma MMP9 levels in patients during the long-term period following myocardial revascularisation. We aimed to investigate the role of MMP9 in relation to myocardial status before and after myocardial revascularisation and to assess its long-term prognostic value.
methodsThis prospective observational study included 200 male patients with ischaemic heart disease. All patients underwent direct myocardial revascularisation on a beating heart (off-pump surgery). Plasma MMP9 levels were analysed preoperatively, at 48 h postoperatively, and during the long-term follow-up period (one year postoperatively). Key echocardiographic parameters, specifically left ventricular ejection fraction (LVEF) and Left Ventricular End-Diastolic Volume (LVEDV), were also assessed.
resultsMMP9 levels decreased significantly at 48 h postoperatively (
conclusionsOur study established an association between 1-year postoperative MMP9 levels and key parameters of left ventricular function during the long-term follow-up period. This suggests that MMP9 may serve as a novel biomarker for predicting outcomes following myocardial revascularisation.
Indexed as
biomarkerischaemic heart diseasematrix metalloproteinase 9 (MMP9)myocardial revascularisation
Identifiers
PMID40566560
PMCPMC12194191
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