Evidence map›Paper›PMID 40566552›Full record

ArticleLife (Basel, Switzerland)2025

DuoStim Shows Comparable Efficacy but Better Efficiency than Two Conventional Stimulations in Poor/Suboptimal Responders Undergoing Vitrified Oocyte Accumulation for PGT-A.

Stefano Canosa, Alberto Revelli, Danilo Cimadomo, Alberto Vaiarelli, Gianluca Gennarelli, Daniela Guidetti, Andrea Roberto Carosso, Laura Rienzi, Filippo Maria Ubaldi, Francesca Bongioanni

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefano CanosaIVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy.ORCID 0000-0001-6402-6750
Alberto RevelliIVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy.ORCID 0000-0002-5797-3722
Danilo CimadomoIVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, 00197 Rome, Italy.ORCID 0000-0002-5390-9221
Alberto VaiarelliIVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, 00197 Rome, Italy.
Gianluca GennarelliIVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy.ORCID 0000-0003-4390-9428
Daniela GuidettiIVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy.
Andrea Roberto CarossoGynecology and Obstetrics 1U, Physiopathology of Reproduction and IVF Unit, Department of Surgical Sciences, S. Anna Hospital, University of Turin, 10126 Turin, Italy.
Laura RienziIVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, 00197 Rome, Italy.
Filippo Maria UbaldiIVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, 00197 Rome, Italy.
Francesca BongioanniIVIRMA Global Research Alliance, Livet, Via Tiziano Vecellio 3, 10126 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study compared the DuoStim protocol with two conventional follicular phase stimulations for vitrified oocyte accumulation in poor-prognosis patients undergoing PGT-A. A retrospective analysis of 112 IVF cycles was conducted, with 66 cycles among patients undergoing DuoStim (DS-Group) and 46 among patients undergoing conventional follicular phase stimulations (DF-Group). The primary outcome was the time to live birth, while secondary outcomes included clinical pregnancy rate, miscarriage rate, live birth rate, and cumulative live birth rate. The final analysis included 66 patients in the DS-Group and 40 in the DF-Group, as 6 women (13%) in the DF-Group discontinued treatment after the first stimulation. Oocyte yield was similar between groups (8.4 ± 3.9 in DS-Group vs. 8.2 ± 4.0 in DF-Group,

Indexed as

DuoStimfollicular phase stimulationoocyte accumulationoocyte vitrificationtime to live birth

Identifiers

PMID40566552
PMCPMC12193753

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.