ReviewLife (Basel, Switzerland)2025
Literature Review of Prognostic Factors in Secondary Generalized Peritonitis.
Review in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Clinical Utility of Circulating Biomarkers for Diagnosis and Prognosis of Acute Stroke in the Emergency Department: A Narrative Review from Current Evidence to Clinical Implementation.Diagnostics (Basel, Switzerland) · 2026Review
- Clinical Performance of BIO-S and BIO-SC Composite Bioscores for 28-Day Mortality Stratification in Adults with Sepsis and Septic Shock.Biomedicines · 2026Article
- Depressive Symptoms in Pediatric Tuberculosis: A Retrospective Two-Time-Point Observational Study.Diseases (Basel, Switzerland) · 2026Article
- Development and Validation of a Predictive Model for Surgical Site Infection in Open Hand Injuries.Infection and drug resistance · 2026Article
- A Novel Composite Bioscore Integrating Biomarkers, Clinical Scores, and Comorbidity Indices for Prognostic Stratification in Sepsis.Journal of inflammation research · 2026Article
- Phagocyte NADPH Oxidase NOX2-Derived Reactive Oxygen Species in Antimicrobial Defense: Mechanisms, Regulation, and Therapeutic Potential-A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Generalized secondary peritonitis is a life-threatening intra-abdominal infection requiring urgent surgical intervention. Despite advances in surgical and antimicrobial therapy, morbidity and mortality remain high. Identifying key prognostic factors is crucial for improving patient outcomes. This review examines significant prognostic indicators and explores the potential role of scoring systems and artificial intelligence in risk stratification. A review was conducted using PubMed, Web of Science, Scopus, and Medline databases. Studies published from 2000 to 2024 focusing on prognostic factors in secondary peritonitis were included. A total of 145 studies were identified, with 40 selected based on relevance and methodological quality. Data extraction included patient demographics, comorbidities, severity scores, microbiological profiles, and artificial intelligence applications in peritonitis management. Poor prognosis was associated with advanced age, severe sepsis, organ failure, chronic kidney disease, cardiovascular comorbidities, and diabetes mellitus. The Mannheim Peritonitis Index (MPI) remains a widely validated prognostic tool, while APACHE II and SOFA scores also provide valuable risk estimates. Increasing multidrug-resistant infections further complicate management and impact outcomes. Emerging evidence suggests that machine learning algorithms may improve early risk stratification and individualized outcome prediction when integrated with conventional scoring systems. Identifying prognostic factors remains essential for optimizing outcomes in secondary peritonitis, and future research should prioritize the clinical validation and integration of AI-based models into perioperative management protocols.
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Registered trials
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