Evidence map›Paper›PMID 40566507›Full record

ArticleLife (Basel, Switzerland)2025

Validation of the Measurement of Beta-Hydroxybutyrate and Non-Esterified Fatty Acids in Bovine Saliva: A Pilot Report.

Camila P Rubio, Lucas Rigueira, Marta Miranda, Pedro Javier Vallejo, Jesús Semitiel, David Del Olmo, María D Contreras-Aguilar, Flávio G Silva, Elsa Lamy, Christian De la Fe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Camila P RubioInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain.ORCID 0000-0002-9293-4147
Lucas RigueiraDepartamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Servicio de Animales de Renta, Hospital Veterinario Universitario Rof-Codina, Facultad de Veterinaria, Campus Terra, Universidad de Santiago de Compostela, 27002 Lugo, Spain.
Marta MirandaDepartamento de Anatomía, Producción Animal y Ciencias Clínicas Veterinarias, Servicio de Animales de Renta, Hospital Veterinario Universitario Rof-Codina, Facultad de Veterinaria, Campus Terra, Universidad de Santiago de Compostela, 27002 Lugo, Spain.ORCID 0000-0002-9869-3874
Pedro Javier VallejoInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain.
Jesús SemitielJISAP, 30817 Lorca, Spain.
David Del OlmoJISAP, 30817 Lorca, Spain.
María D Contreras-AguilarInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain.
Flávio G SilvaMED-Mediterranean Institute for Agriculture, Environment and Development, University of Évora, Pólo da Mitra, Ap. 94, 7006-554 Évora, Portugal.ORCID 0000-0003-4218-498X
Elsa LamyMED-Mediterranean Institute for Agriculture, Environment and Development, University of Évora, Pólo da Mitra, Ap. 94, 7006-554 Évora, Portugal.ORCID 0000-0002-9370-1337
Christian De la FeRuminant Health Research Group, Department of Animal Health, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.ORCID 0000-0002-4354-1689
José J CerónInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain.
Fernando TeclesInterdisciplinary Laboratory of Clinical Analysis (Interlab-UMU), Veterinary School, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain.

Funding

Ministerio de Ciencia e Innovación, Spain MCIN/AEI/10.13039/501100011033Séneca foundation. Murcia, Spain 22034/PI/22
6 · The paper itself

Abstract

Serum beta-hydroxybutyrate (BHB) and non-esterified fatty acids (NEFAs) are biomarkers of situations of negative energetic balance in bovine. However, knowledge about their possible measurement and use in saliva is limited. In this report, two commercially available methods for the measurement of BHB and NEFAs were validated for use in bovine saliva. Both methods showed good precision and accuracy. The BHB concentrations were correlated between the saliva and the serum, but not the NEFA concentrations. The cows with hyperketonemia (

Indexed as

biomarkersbovineenergy balanceketone bodiessaliva

Identifiers

PMID40566507
PMCPMC12194772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.