ArticleEntropy (Basel, Switzerland)2025
Fisher Information and the Dynamics of Multicellular Ageing.
Article in Entropy (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Information theory has long been integrated into the study of biological ageing, for example, in examining the roles of genetic and epigenetic fidelity in cellular and organismal longevity. Here, we introduce a theoretical model that interprets ageing in multicellular systems through the lens of Fisher information. Previous theories have suggested that the ageing of multicellular organisms is an inevitable consequence of the inherent tension between individual cell reproduction and the homeostasis of the multicellular system. Utilising concepts from information theory and statistical mechanics, we show that Fisher information parametrises the dynamics of this tension through non-monotonic behaviour, which depends on an optimal balance of competition and cooperation between cells. Moreover, Fisher information suggests that the ability to infer true biological age from a sample evolves through complex dynamics over an organism's lifespan.
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