Evidence map›Paper›PMID 40565990›Full record

ArticleJournal of clinical medicine2025

Safety, Cognitive, and Behavioral Outcomes in Patients with Dementia with Lewy Bodies Treated with Nilotinib.

Fernando Pagan, Yasar Torres-Yaghi, Michaeline Hebron, Barbara Wilmarth, R Scott Turner, Sara Matar, Xiaoguang Liu, Dalila Ferrante, Giuseppe Esposito, Jaeil Ahn and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernando PaganTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Yasar Torres-YaghiTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Michaeline HebronTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Barbara WilmarthTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
R Scott TurnerMemory Disorders Program, Department of Neurology, Georgetown University Medical Center, Suite 177, Building D, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Sara MatarTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Xiaoguang LiuTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Dalila FerranteTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.
Giuseppe EspositoDivision of Nuclear Medicine, Department of Radiology, MedStar Georgetown Hospital, Bles Building, 2nd Floor, 3300 Reservoir Rd NW, Washington, DC 20057, USA.
Jaeil AhnDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Basic Science Building, 3800 Reservoir Rd NW, Washington, DC 20057, USA.ORCID 0000-0001-7998-4759
Charbel MoussaTranslational Neurotherapeutics Program, Laboratory for Dementia and Parkinsonism, Department of Neurology, Lewy Body Dementia Association Research Center of Excellence, Georgetown University Medical Center, Building D, Room 265, 4000 Reservoir Rd NW, Washington, DC 20057, USA.ORCID 0000-0002-2012-7063

Funding

Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1RR031975 · NCRR · GEORGETOWN UNIVERSITY · PI VERBALIS, JOSEPH G · 2010 to 2011
$14.6M
A randomized, double blind, placebo-controlled study to evaluate the impact of Nilotinib treatment on safety, tolerability, pharmacokinetics and biomarkers in Dementia with Lewy Bodies (DLB)R01AG062463 · NIA · GEORGETOWN UNIVERSITY · PI MOUSSA, CHARBEL · 2019 to 2022
$6.4M
NCATS NIH HHS UL1 TR000101NCRR NIH HHS UL1 RR031975NIA NIH HHS R01 AG062463NIH HHS 1R01AG062463-19
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer’s diseasedementia with Lewy bodiesdopaminefallshyper-phosphorylated tau

Identifiers

PMID40565990
PMCPMC12194573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.