Evidence map›Paper›PMID 40565918›Full record

ReviewJournal of clinical medicine2025

Pulmonary Metastasectomy for Colorectal Cancer: Evidence and Outcomes-A Narrative Review.

Athanasios Papatriantafyllou, Konstantinos Grapatsas, Francesk Mulita, Nikolaos G Baikoussis, Elias Liolis, Levan Tchabashvili, Konstantinos Tasios, Spyros Papadoulas, Manfred Dahm, Vasileios Leivaditis

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Athanasios PapatriantafyllouDepartment of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, 67655 Kaiserslautern, Germany.
Konstantinos GrapatsasDepartment of Thoracic Surgery and Thoracic Endoscopy, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, 45141 Essen, Germany.
Francesk MulitaDepartment of General Surgery, General Hospital of Eastern Achaia-Unit of Aigio, 25100 Aigio, Greece.ORCID 0000-0001-7198-2628
Nikolaos G BaikoussisDepartment of Cardiac Surgery, Ippoktration Gernaral Hospital of Athens, 11527 Athens, Greece.ORCID 0000-0001-5645-662X
Elias LiolisDepartment of Oncology, University Hospital of Patras, 26504 Patras, Greece.
Levan TchabashviliDepartment of General Surgery, General Hospital of Eastern Achaia-Unit of Aigio, 25100 Aigio, Greece.
Konstantinos TasiosDepartment of General Surgery, General University Hospital of Patras, 26504 Patras, Greece.
Spyros PapadoulasDepartment of Vascular Surgery, University Hospital of Patras, 26504 Patras, Greece.
Manfred DahmDepartment of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, 67655 Kaiserslautern, Germany.
Vasileios LeivaditisDepartment of Cardiothoracic and Vascular Surgery, Westpfalz Klinikum, 67655 Kaiserslautern, Germany.ORCID 0000-0001-8692-0059

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary metastasectomy for colorectal cancer represents a key component in modern oncological surgery, balancing precision resection with systemic disease management. Despite ongoing debate initiated by randomized trials, the surgical removal of lung metastases continues to offer significant survival benefits in well-selected patients. This review synthesizes the evolving landscape of pulmonary metastasectomy, integrating classical prognostic indicators, such as the disease-free interval (DFI) and carcinoembryonic antigen (CEA) levels, with emerging molecular insights including KRAS and BRAF mutations. The relationship between surgical radicality, systemic therapies, and personalized genetic profiling is redefining patient selection and optimizing outcomes. By dissecting recent evidence and ongoing controversies, we clarify the complex decision-making required to navigate this complex clinical terrain. Ultimately, the synergy of multidisciplinary care and precision surgery holds the promise of durable disease control and extended survival in colorectal cancer patients with lung metastases.

Indexed as

colorectal cancerprognostic factorspulmonary metastasectomypulmonary metastasessurgical outcomessurvival

Identifiers

PMID40565918
PMCPMC12194342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.