Evidence map›Paper›PMID 40565873›Full record

ReviewJournal of clinical medicine2025

Respiratory Manifestations and Their Physical, Psychological, and Social Impacts in Ehlers-Danlos Syndromes and Generalized Hypermobility Spectrum Disorders: A Narrative Review.

Noor Al Kaabi, Encarna Camacho, Ani Orchanian-Cheff, Vanessa Silano, Laura McGillis, Wing Ting Truong, W Darlene Reid, Chung-Wai Chow, Clodagh M Ryan, Maxwell Slepian and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Noor Al KaabiDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.
Encarna CamachoDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.
Ani Orchanian-CheffLibrary and Information Services, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0002-9943-2692
Vanessa SilanoDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.
Laura McGillisGoodHope Ehlers-Danlos Syndrome Program, University Health Network, Toronto, ON M5G 2C4, Canada.
Wing Ting TruongGoodHope Ehlers-Danlos Syndrome Program, University Health Network, Toronto, ON M5G 2C4, Canada.
W Darlene ReidKITE-Toronto Rehab, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-9980-8699
Chung-Wai ChowDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.
Clodagh M RyanDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0002-2372-965X
Maxwell SlepianGoodHope Ehlers-Danlos Syndrome Program, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0003-0435-4191
Daniel Santa MinaGoodHope Ehlers-Danlos Syndrome Program, University Health Network, Toronto, ON M5G 2C4, Canada.
Hance ClarkeTemerty Faculty of Medicine, University of Toronto, Toronto, ON M5R 0A3, Canada.ORCID 0000-0003-4975-3823
Nimish MittalTemerty Faculty of Medicine, University of Toronto, Toronto, ON M5R 0A3, Canada.ORCID 0000-0002-6291-1956
Dmitry RozenbergDivision of Respirology, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-8786-9152

Funding

DR receives research support from the Sandra Faire and Ivan Fecan Professorship in Rehabilitation Medicine and Temerty Faculty of Medicine. Not applicableNAK received financial research support from the Canadian Institute of Health Research Canada Graduate Scholarship-Master's Program. Not applicableThis research is funded by the GoodHope Ehlers-Danlos Syndrome foundation at the University Health Network. Not applicable
6 · The paper itself

Abstract

Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum disorders (G-HSD) are a group of genetic, connective multi-systemic disorders that can affect the musculoskeletal, gastrointestinal, cardiovascular, and respiratory systems. Respiratory manifestations in EDS/G-HSD can contribute to decrements in health-related quality of life (HRQL); however, these relationships have not been previously characterized. We aimed to review the association of respiratory manifestations with the physical, psychological, and social domains of HRQL in EDS/G-HSD. A comprehensive search was conducted using Ovid Medline, Embase, and CINAHL with the following terms: "Ehlers-Danlos Syndrome", "Hypermobility Spectrum Disorders", and "Quality of Life". Selected studies in English that investigated the relationship between respiratory manifestations and HRQL domains in EDS/G-HSD were included in this narrative review from inception to March 2024. Twelve studies described the physical, psychological, or social domains of HRQL relating to respiratory manifestations. Dyspnea, wheezing, and expiratory flow limitations were associated with limitations in physical function and exercise intolerance. Respiratory manifestations were associated with increased fatigue, pain, anxiety, kinesiophobia, and deconditioning. This review highlights the consequences that respiratory manifestations have on the physical domains of HRQL, through limitations on physical activity and exercise. Future studies should aim to identify the impact that respiratory manifestations have on the psychosocial domains of HRQL and develop disease-specific patient-reported measures to evaluate these relationships.

Indexed as

Ehlers-Danlos syndromeshealth-related quality of lifepatient-reported outcome measuresrespiratorysigns and symptoms

Identifiers

PMID40565873
PMCPMC12194458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.