Evidence map›Paper›PMID 40565639›Full record

ArticleFoods (Basel, Switzerland)2025

Study of the Stability and Anti-Inflammatory Activity of Paeonol-Oleanolic Acid Liposomes by Microfluidic Technology.

Xianzheng Ma, Hui Zhang, Jinkai Luan, Mingfa Tian, Xiuxin Zhang, Ammara Sohail, Dong Liang, Jiguo Liu, Fuzhan Tao, Zheng Wang and 1 more

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xianzheng MaCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.
Hui ZhangCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.
Jinkai LuanCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.
Mingfa TianCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.ORCID 0009-0005-2495-951X
Xiuxin ZhangInstitute of Vegetables and Flowers, Chinese Academy of Agricultural Science, Beijing 100081, China.ORCID 0000-0001-8465-7365
Ammara SohailCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.ORCID 0000-0001-7725-0188
Dong LiangHeze Peony Industrial Technology Research Institute, Heze 274000, China.
Jiguo LiuHeze Peony Industrial Technology Research Institute, Heze 274000, China.
Fuzhan TaoHeze Peony Industrial Technology Research Institute, Heze 274000, China.
Zheng WangDepartment of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266071, China.ORCID 0000-0003-4471-5983
Daijie WangCollege of Pharmacy, Food Resources Development and Health Product Creation International Joint Laboratory/Biological Engineering Technology Innovation Center of Shandong Province, Heze Branch of Qilu University of Technology, Shandong Academy of Sciences, Heze 274000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: This study used a microfluidic approach to prepare paeonol (PAE) liposomes with oleanolic acid (PAE-ONLs) instead of cholesterol (PAE-CNLs), aiming to reduce cholesterol levels and enhance stability and anti-inflammatory activity. (2) Methods: The liposome formula was optimized, characterized, and tested for anti-inflammatory activities in zebrafish and RAW 264.7 macrophages, utilizing various stability and molecular interaction methods. (3) Results: The best PAE-ONL preparation conditions were 10.25 mg/mL of soy lecithin, 0.82 mg/mL of oleanolic acid, and 0.22% (wt%) of Tween 80, with an

Indexed as

anti-inflammatory activitycholesterolliposomeoleanolic acidpaeonol

Identifiers

PMID40565639
PMCPMC12191921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.