Evidence map›Paper›PMID 40565590›Full record

ArticleGenes2025

Direct Oral Anticoagulant-Related Bleeding in Atrial Fibrillation Patients Leads to

Georgia Ragia, Thomas Thomopoulos, Myria Pallikarou, Natalia Atzemian, Anthi Maslarinou, Georgios Chalikias, Athanasios Trikas, Dimitrios N Tziakas, Vangelis G Manolopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rare TruncatingGenes · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georgia RagiaLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0000-0002-2421-5677
Thomas ThomopoulosDepartment of Cardiology, "Elpis" General Hospital of Athens, 11522 Athens, Greece.
Myria PallikarouLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0009-0008-0918-5773
Natalia AtzemianLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0009-0005-7793-7082
Anthi MaslarinouLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.
Georgios ChalikiasCardiology Department, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0000-0003-4331-730X
Athanasios TrikasDepartment of Cardiology, Evaggelismos Hospital, 10676 Athens, Greece.
Dimitrios N TziakasCardiology Department, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0000-0002-4982-9181
Vangelis G ManolopoulosLaboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0849-5469

Funding

NSRF 2014-2020 MIS 5047189
6 · The paper itself

Abstract

BACKGROUND/

objectivesAmong other substrates, the a disintegrin and metalloproteinase with thrombospondin motifs 7 (

methodsEighty-four DOAC-treated atrial fibrillation (AF) patients followed-up from baseline (t0) to 7 days (t1,

resultsA total of 16 minor bleeding events occurred. The baseline percentage of

conclusions

Indexed as

ADAMTS7 ProteinAnticoagulantsAtrial FibrillationDNA MethylationHemorrhagePromoter Regions, GeneticAdministration, OralAgedDemethylationEpigenesis, GeneticFemaleHumansMaleMiddle AgedADAMTS7 ProteinADAMTS7 protein, humanAnticoagulantsADAMTS7apixabandabigatrandirect oral anticoagulantsepigeneticsmethylationmiR-CRAFT studyrivaroxaban

Identifiers

PMID40565590
PMCPMC12192494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.