Evidence map›Paper›PMID 40565560›Full record

ArticleGenes2025

Serum Markers of Bone Turnover and Bone Remodeling in Children with Noonan Syndrome: Genotype-Phenotype Correlation.

Mariangela Chiarito, Ilaria Farella, Crescenza Lattanzio, Rossella Vitale, Flavia Urbano, Pietro Guida, Laura Piacente, Paola Muggeo, Maria Felicia Faienza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mariangela ChiaritoGiovanni XXIII Pediatric Hospital, University of Bari "A. Moro", 70124 Bari, Italy.
Ilaria FarellaDepartment of Medicine and Surgery, LUM University, 70010 Casamassima, Italy.ORCID 0000-0003-0002-7396
Crescenza LattanzioGiovanni XXIII Pediatric Hospital, University of Bari "A. Moro", 70124 Bari, Italy.
Rossella VitaleGiovanni XXIII Pediatric Hospital, University of Bari "A. Moro", 70124 Bari, Italy.
Flavia UrbanoGiovanni XXIII Pediatric Hospital, University of Bari "A. Moro", 70124 Bari, Italy.
Pietro GuidaNeonatology Department, Regional General Hospital "F. Miulli", 70021 Bari, Italy.
Laura PiacentePediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University "A. Moro", 70124 Bari, Italy.
Paola MuggeoDepartment of Pediatric Oncology and Hematology, University Hospital of Policlinic, 70124 Bari, Italy.ORCID 0000-0001-8813-3200
Maria Felicia FaienzaPediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University "A. Moro", 70124 Bari, Italy.ORCID 0000-0002-1899-8337

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noonan syndrome (NS) is a genetic disorder characterized by distinctive craniofacial and skeletal features, short stature, mild to moderate developmental impairment, and multisystem involvement, notably affecting the cardiovascular, musculoskeletal, and endocrine systems. Although abnormalities of the bone matrix, as well as osteopenia and osteoporosis, are well recognized in individuals with NS and other RASopathies, the specific impact of RAS/MAPK pathway dysregulation on bone health remains poorly understood.

Indexed as

BiomarkersBone RemodelingNoonan SyndromeAdolescentBone DensityCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesFemaleGenetic Association StudiesHumansMaleRANK LigandBiomarkersRANK Ligandbone mineral densitybone remodeling markersbone turnover markersNoonan syndromeRAS/MAPK pathway

Identifiers

PMID40565560
PMCPMC12193694

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.