The Complex Role of the miR-17-92 Cluster in Stroke: Mechanistic Insights and Biomarker Potential.

Stroke is a leading cause of morbidity and mortality worldwide, with ischemic stroke (IS) accounting for approximately 85% of cases. Recent research has highlighted the critical role of microRNAs (miRNAs), a class of small non-coding RNA molecules, in the pathogenesis of stroke. Among these, the miR-17-92 cluster and its paralogs have emerged as key regulators in the development of stroke pathology and the subsequent recovery processes. We emphasize their regulatory roles in key pathological processes, including inflammation, apoptosis, neuroprotection, and tissue repair. We provide an overview of these mechanisms to support the identification of novel miRNA-based therapeutic targets and to improve stroke diagnosis, treatment, and recovery strategies. Specific miRNAs, such as miR-19a, miR-18a, and miR-92a, contribute to processes including neurogenesis, axonal growth, and a reduction in neuronal apoptosis. The miR-17-92 cluster also offers potential therapeutic applications by targeting injury-induced pathways, such as modulating apoptosis, promoting axonal elongation, or inhibiting neurodegeneration. Preclinical studies have suggested their potential to enhance neural regeneration and promote functional recovery. Future research should further elucidate the regulatory mechanisms of the miR-17-92 members and their therapeutic potential to enhance stroke treatment strategies.