Evidence map›Paper›PMID 40565540›Full record

ReviewGenes2025

A Comprehensive Review of Deep Learning Applications with Multi-Omics Data in Cancer Research.

Flavio Sartori, Francesco Codicè, Isabella Caranzano, Cesare Rollo, Giovanni Birolo, Piero Fariselli, Corrado Pancotti

Abstract readReview
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Flavio SartoriComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0009-0004-3833-6551
Francesco CodicèComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0009-0001-6458-9075
Isabella CaranzanoComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0009-0004-8310-0652
Cesare RolloComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0000-0001-6093-1454
Giovanni BiroloComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0000-0003-0160-9312
Piero FariselliComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0000-0003-1811-4762
Corrado PancottiComputational Biomedicine Unit, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.ORCID 0000-0003-2327-1148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of deep learning (DL) with multi-omics data has significantly advanced our understanding of biological systems, particularly in cancer research. DL enables the analysis of high-dimensional datasets and the discovery of novel disease mechanisms and biomarkers, contributing to improved patient treatment and management. This review provides a detailed overview of recent developments in deep learning models applied to genomics data, with a focus on cancer type classification, driver gene identification, survival analysis, and drug response prediction. We introduce the foundational concepts of machine and deep learning and explain the characteristics of multi-omics data, addressing a broad and interdisciplinary audience. Methods published since 2020 are systematically reviewed, including their model architectures, datasets, and key innovations.

Indexed as

Computational BiologyDeep LearningGenomicsNeoplasmsBiomarkers, TumorHumansMultiomicsBiomarkers, Tumorcancer genomicsdeep learningdrug responsemulti-omicssurvival analysis

Identifiers

PMID40565540
PMCPMC12191839

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.