Evidence map›Paper›PMID 40565537›Full record

ArticleGenes2025

Clinical Efficacy of Selumetinib in Alleviating Neuropathic Pain Associated with Plexiform Neurofibroma: A Case Series.

Giuseppina Miele, Irene Russo, Lorenzo Filipponi, Silverio Perrotta, Elisabetta Maida, Giulio Piluso, Mariarosa Anna Beatrice Melone, Claudia Santoro

Abstract readCase Reports
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Management of plexiform neurofibromas in neurofibromatosis type 1: An Italian Delphi consensus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuseppina MieleDepartment of Advanced Medical and Surgical Sciences, InterUniversity Center for Research in Neurosciences and Center for Rare Diseases, 2nd Division of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Irene RussoDepartment of Women's and Children's Health and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138 Naples, Italy.
Lorenzo FilipponiDepartment of Women's and Children's Health and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138 Naples, Italy.
Silverio PerrottaDepartment of Women's and Children's Health and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138 Naples, Italy.ORCID 0000-0001-6149-6845
Elisabetta MaidaDepartment of Advanced Medical and Surgical Sciences, InterUniversity Center for Research in Neurosciences and Center for Rare Diseases, 2nd Division of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giulio PilusoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0001-9418-125X
Mariarosa Anna Beatrice MeloneDepartment of Advanced Medical and Surgical Sciences, InterUniversity Center for Research in Neurosciences and Center for Rare Diseases, 2nd Division of Neurology, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-7213-9277
Claudia SantoroDepartment of Women's and Children's Health and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138 Naples, Italy.ORCID 0000-0003-4547-0500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BenzimidazolesNeuralgiaNeurofibroma, PlexiformNeurofibromatosis 1Protein Kinase InhibitorsAdolescentAdultFemaleHumansMaleTreatment OutcomeYoung AdultAZD 6244BenzimidazolesProtein Kinase InhibitorsMEK inhibitorneurofibromatosis type 1neuropathic painplexiform neurofibromaselumetinib

Identifiers

PMID40565537
PMCPMC12192340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.