Evidence map›Paper›PMID 40565366›Full record

ArticleInternational journal of molecular sciences2025

Comparison Bioinformatic Analysis of Extracellular Vesicles-Related Genes and MicroRNAs in Breast Cancer.

Durmus Ayan, Serife Buket Bozkurt Polat, Esma Ozmen, Mehmet Ali Gul

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Durmus AyanFaculty of Medicine, Medical Biochemistry, Nigde Omer Halisdemir University, 51100 Nigde, Türkiye.ORCID 0000-0003-2615-8474
Serife Buket Bozkurt PolatFaculty of Medicine, Medical Biochemistry, Nigde Omer Halisdemir University, 51100 Nigde, Türkiye.
Esma OzmenFaculty of Medicine, Medical Biochemistry, Nigde Omer Halisdemir University, 51100 Nigde, Türkiye.
Mehmet Ali GulFaculty of Medicine, Medical Biochemistry, Amasya University, 05200 Amasya, Türkiye.ORCID 0000-0002-5849-0116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with treatment challenges due to the lack of targeted therapies. Extracellular vesicles (EVs) play a crucial role in BC progression by carrying bioactive molecules. This study analyzed EV-associated molecules (ENPEP, TIMP1, CD36, MARCKS, DAB2, CXCL14, miR-181b-5p, miR-222-3p) using bioinformatics tools. We used GEPIA2; Human Protein Atlas (HPA) 24.0; bc-GenExMiner v5.1; UALCAN 2022; Kaplan-Meier plotter 2025; ENCORI database v2.0; Enrichr-KG web tool 2021; Cancer Hallmark Enrichment tool 2025; Tumor, Normal, and Metastatic (TNM) plot database 2025; MicroRNA Target Prediction Database 6.0; TargetScan 8.0; and STRING database 12.0. CD36, DAB2, and CXCL14 were significantly downregulated, while TIMP1 was upregulated in BC tissues (

Indexed as

Breast NeoplasmsComputational BiologyExtracellular VesiclesMicroRNAsBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansBiomarkers, TumorMicroRNAsbiomarkersbreast cancerextracellular vesicles

Identifiers

PMID40565366
PMCPMC12192915

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.