Evidence map›Paper›PMID 40565365›Full record

ArticleInternational journal of molecular sciences2025

Retinal BMI1 Expression Preserves Photoreceptors in Sodium-Iodate-Induced Oxidative Stress Models.

Zhongyang Lu, Shufeng Liu, Maria G Morales, Andy Whitlock, Ram Ramkumar, Hema L Ramkumar

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Protective Effects ofJournal of microbiology and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhongyang LuOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.ORCID 0000-0002-2182-7854
Shufeng LiuOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.
Maria G MoralesOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.ORCID 0000-0001-7249-4597
Andy WhitlockOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.
Ram RamkumarOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.
Hema L RamkumarOculogenex Inc., 2250 W Whittier Blvd., Suite 300, La Habra, CA 90631, USA.ORCID 0000-0002-1452-0694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry age-related macular degeneration (AMD) is a leading cause of vision loss in individuals over 50, yet no approved therapies exist for early or intermediate stages of the disease. Oxidative stress is a central driver of retinal degeneration in AMD, and sodium iodate (NaIO

Indexed as

IodatesMacular DegenerationOxidative StressPhotoreceptor Cells, VertebratePolycomb Repressive Complex 1RetinaAnimalsDependovirusDisease Models, AnimalElectroretinographyMiceMice, Inbred BALB CMice, Inbred C57BLProto-Oncogene ProteinsRetinal Pigment EpitheliumTomography, Optical CoherenceBmi1 protein, mouseIodatesPolycomb Repressive Complex 1Proto-Oncogene Proteinssodium iodateAAV gene therapyage-related macular degenerationBMI1retinaretinal pigment epitheliumsodium iodate

Identifiers

PMID40565365
PMCPMC12193584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.