Evidence map›Paper›PMID 40565364›Full record

ArticleInternational journal of molecular sciences2025

Exploring Carboxamide Derivatives as Promising Anticancer Agents: Design, In Vitro Evaluation, and Mechanistic Insights.

Manal M Al-Najdawi, Maysaa M Saleh, Dima A Sabbah, Rima Hajjo, Hiba Zalloum, Suha M Abudoleh, Duaa A Abuarqoub, Yusuf M Al-Hiari, Mohammad Yasin Mohammad, Husam ALSalamat and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manal M Al-NajdawiDepartment of Pharmaceutical Technology and Cosmetics, Faculty of Pharmacy Middle East University, Amman 11831, Jordan.ORCID 0000-0003-4372-997X
Maysaa M SalehDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman 11622, Jordan.ORCID 0000-0002-3140-4038
Dima A SabbahDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0003-1428-5097
Rima HajjoDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.ORCID 0000-0002-7090-5425
Hiba ZalloumHamdi Mango Center for Scientific Research, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0002-5296-2776
Suha M AbudolehDepartment of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Middle East University, Amman 11831, Jordan.ORCID 0000-0001-7934-8250
Duaa A AbuarqoubDepartment of Pharmaceutical and Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan.ORCID 0000-0001-5277-5703
Yusuf M Al-HiariDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-4416-9193
Mohammad Yasin MohammadPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.ORCID 0000-0002-0641-1586
Husam ALSalamatHamdi Mango Center for Scientific Research, The University of Jordan, Amman 11942, Jordan.ORCID 0000-0003-3455-7491
Hebah MansourDepartment of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Isra University, Amman 11622, Jordan.ORCID 0009-0004-1202-7830
Nawzat D AljbourDepartment of Pharmaceutical Technology and Cosmetics, Faculty of Pharmacy Middle East University, Amman 11831, Jordan.ORCID 0000-0002-5714-3753
Aktham H MestareehiDepartment of Applied Pharmaceutical Sciences and Clinical Pharmacy, Faculty of Pharmacy, Isra University, Amman 11622, Jordan.ORCID 0000-0002-1478-6310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carboxamide derivatives are a promising class of compounds in anticancer drug discovery, owing to their ability to interact with multiple oncogenic targets and their favorable pharmacological profiles. In this study, we report the design, synthesis, and biological evaluation of a series of

Indexed as

Antineoplastic AgentsDrug DesignIndolesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHCT116 CellsHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsIndolescarboxamidescheminformaticsmolecular dockingMTT assayprincipal component analysis

Identifiers

PMID40565364
PMCPMC12193374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.