Evidence map›Paper›PMID 40565357›Full record

ArticleInternational journal of molecular sciences2025

Analysis of the Expression Patterns of Tumor Necrosis Factor Alpha Signaling Pathways and Regulatory MicroRNAs in Astrocytic Tumors.

Klaudia Skóra, Damian Strojny, Dawid Sobański, Rafał Staszkiewicz, Paweł Gogol, Mateusz Miller, Beniamin Oskar Grabarek

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Klaudia SkóraDepartment of Neurological Rehabilitation, District Hospital of St. Padre Pio in Sędziszów Małopolski, 39-120 Sędziszów Małopolski, Poland.ORCID 0009-0006-8548-3321
Damian StrojnyCollegium Medicum, WSB University, 41-300 Dąbrowa Górnicza, Poland.
Dawid SobańskiCollegium Medicum, WSB University, 41-300 Dąbrowa Górnicza, Poland.ORCID 0000-0002-5525-6201
Rafał StaszkiewiczCollegium Medicum, WSB University, 41-300 Dąbrowa Górnicza, Poland.ORCID 0000-0002-0781-6534
Paweł GogolCollegium Medicum, WSB University, 41-300 Dąbrowa Górnicza, Poland.
Mateusz MillerDepartment of Neurology, Independent Public Healthcare Institution of the Ministry of Internal Affairs and Administration in Rzeszów, 35-111 Rzeszów, Poland.
Beniamin Oskar GrabarekCollegium Medicum, WSB University, 41-300 Dąbrowa Górnicza, Poland.ORCID 0000-0003-1633-7145

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammation is increasingly recognized as a driver of glioma progression, with tumor necrosis factor-alpha (TNF-α) playing a central role in modulating the tumor microenvironment. This study aimed to investigate the expression profiles and regulatory mechanisms of TNF-α and its downstream mediators-including interleukin-1 beta (IL-1β), Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8), and Mitogen-activated protein kinase kinase

Indexed as

AstrocytomaBrain NeoplasmsGene Expression Regulation, NeoplasticMicroRNAsSignal TransductionTumor Necrosis Factor-alphaAdultAgedDNA MethylationFemaleGene Expression ProfilingHumansInterleukin-1betaMaleMAP Kinase Kinase KinasesMiddle AgedInterleukin-1betaMAP Kinase Kinase KinasesMicroRNAsTumor Necrosis Factor-alphaastrocytomaIL-1βMAP3K8methylationmicroRNAtumor necrosis factor alpha

Identifiers

PMID40565357
PMCPMC12192942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.