Genomic Profile and Clinical Outcomes in Acute Myeloid Leukemia with Monosomal Karyotype.

Collins Wangulu, Ehsan Bahrami Hezaveh, Mojgan Zarif, Qianghua Zhou, Winnie Lo, Cuihong Wei, Hassan Sibai, Hong Chang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Collins WanguluPrincess Margaret Cancer Biobank (PMCB), University Health Network, Toronto, ON M5G 2C4, Canada.

Ehsan Bahrami HezavehDepartment of Laboratory Hematology, University Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0009-0007-9518-9879

Mojgan ZarifDepartment of Laboratory Hematology, University Health Network, Toronto, ON M5G 2C4, Canada.

Qianghua ZhouDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1V4, Canada.ORCID 0000-0001-7483-0478

Winnie LoDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1V4, Canada.

Cuihong WeiDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1V4, Canada.

Hassan SibaiDepartment of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-9030-8583

Hong ChangDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1V4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biology of Monosomal Karyotype Acute Myeloid Leukemia (MK AML) remains unclear, and its mutational profile has not been exclusively assessed. We sought to determine the genomic profile of MK AML patients and its correlation with overall survival (OS). We conducted a retrospective study involving 664 AML patients, identifying 156 (23.5%) with MK AML. The most common monosomies were -17 (41%) and -7 (37%), with 149 (95%) and 138 (88%) having myelodysplasia-related (

Indexed as

Leukemia, Myeloid, AcuteMonosomyAdolescentAdultAgedAged, 80 and overDNA Methyltransferase 3AFemaleGenomicsHumansIsocitrate DehydrogenaseKaryotypeKaryotypingMaleMiddle AgedMutationDNA Methyltransferase 3ADNMT3A protein, humanIsocitrate DehydrogenaseTP53 protein, humanTumor Suppressor Protein p53Acute Myeloid Leukemiacytogeneticsmonosomal karyotypemutationsoverall survivalTP53 mutation

Identifiers

PMID40565305

DOI10.3390/ijms26125845

PMCPMC12193284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.