Treadmill Exercise-Induced RNA m6A Methylation Modification in the Prevention of High-Fat Diet-Induced MASLD in Mice.

Xueli Liu, Yuanming Zhong, Yuqian Guo, Jianhua Xu, Shaobing Wang, Yiping Liu, Yi Lv, Xi Zheng

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

Aerobic Exercise Alleviates Oxidative Stress and Inflammation to Attenuate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease inMetabolites · 2026
Article

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5 · Who and what money

Authors and funding

8 authors.

Xueli LiuFujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.

Yuanming ZhongSchool of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.

Yuqian GuoFujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.

Jianhua XuSchool of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.

Shaobing WangProvincial University Key Laboratory of Sport and Health Science, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.

Yiping LiuProvincial University Key Laboratory of Sport and Health Science, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.

Yi LvFujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.

Xi ZhengFujian Key Laboratory of Developmental and Neural Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China.ORCID 0000-0002-0019-6459

Funding

National Natural Science Foundation of China 81900535Natural Science Foundation of Fujian Province 2021J05038Natural Science Foundation of Fujian Province 2023J01510

6 · The paper itself

Abstract

Exercise is a well-recognized non-pharmacological strategy for preventing and managing metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as NAFLD). While the benefits of exercise are thought to involve epigenetic mechanisms, the precise role of RNA m6A methylation remains unclear. This study investigates how treadmill exercise modulates RNA m6A methylation to prevent MASLD in a high-fat diet (HFD)-induced mouse model. Male C57BL/6 mice were fed either a standard diet (SD) or HFD for 12 weeks, with a subset of HFD-fed mice undergoing treadmill exercise (HFD + Ex). Liver pathology and biochemical markers were assessed. RNA sequencing (RNA-Seq) and methylated RNA immunoprecipitation sequencing (MeRIP-seq) were performed to identify differentially expressed genes (DEGs) and m6A methylation changes. Key candidate gene

Indexed as

AdenosineDiet, High-FatNon-alcoholic Fatty Liver DiseasePhysical Conditioning, AnimalRNAAnimalsDisease Models, AnimalEpigenesis, GeneticLipid MetabolismLiverMaleMethylationMiceMice, Inbred C57BLRNA MethylationAdenosineRNAaerobic exerciselipid metabolismMeRIP-seqPaqr7RNA-Seq

Identifiers

PMID40565271

DOI10.3390/ijms26125810

PMCPMC12192837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.