Evidence map›Paper›PMID 40565256›Full record

ArticleInternational journal of molecular sciences2025

Binding of Transcriptional Activator to Silent Loci Causes Their Detachment from the Nuclear Lamina in

Ruslan A Simonov, Oxana M Olenkina, Valentina V Nenasheva, Yuri A Abramov, Sergey A Lavrov, Anna A Fedotova, Yuri Y Shevelyov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruslan A SimonovLaboratory of Analysis of Gene Regulation, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-7706-8228
Oxana M OlenkinaLaboratory of Analysis of Gene Regulation, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-9276-2699
Valentina V NenashevaLaboratory of Molecular Neurogenetics and Innate Immunity, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0003-3985-6466
Yuri A AbramovLaboratory of Analysis of Gene Regulation, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.
Sergey A LavrovLaboratory of Biochemical Genetics of Animals, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-4767-6548
Anna A FedotovaDepartment of Regulation of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0003-4420-0883
Yuri Y ShevelyovLaboratory of Analysis of Gene Regulation, National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.ORCID 0000-0002-0568-9236

Funding

Russian Science Foundation 23-14-00049
6 · The paper itself

Abstract

In mammals, the binding of transcriptional activators leads to the repositioning of silent loci from the nuclear periphery to the nuclear interior. However, it remained unknown whether the same mechanism functions in

Indexed as

Drosophila melanogasterDrosophila ProteinsNeuronsNuclear LaminaSalivary GlandsTranscription FactorsAnimalsCell NucleusDrosophilaPolytene ChromosomesProtein BindingDrosophila ProteinsGAL4 protein, DrosophilaTranscription FactorsDrosophilalamina-associated domainneuronsnuclear laminanuclear peripherysalivary glandstranscriptional activator

Identifiers

PMID40565256
PMCPMC12192806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.