Evidence map›Paper›PMID 40565255›Full record

ArticleInternational journal of molecular sciences2025

Progenitor Cell Dynamics in Androgenetic Alopecia: Insights from Spatially Resolved Transcriptomics.

Sasin Charoensuksira, Piyaporn Surinlert, Aungkana Krajarng, Thararat Nualsanit, Witchuda Payuhakrit, Pimchanok Panpinyaporn, Wilunplus Khumsri, Wilai Thanasarnaksorn, Atchima Suwanchinda, Suradej Hongeng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. CRISPR-MediatedCells · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sasin CharoensuksiraDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Piyaporn SurinlertChulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Aungkana KrajarngChulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Thararat NualsanitChulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Witchuda PayuhakritDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0003-4648-4912
Pimchanok PanpinyapornDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Wilunplus KhumsriInterdisciplinary Program of Biomedical Sciences, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
Wilai ThanasarnaksornDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.ORCID 0000-0002-5070-5477
Atchima SuwanchindaDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.ORCID 0000-0002-3432-7090
Suradej HongengDivision of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-7376-9393
Saranyoo PonnikornDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.ORCID 0000-0001-6599-2301

Funding

Thailand Science Research and Innovation Fundamental Fund Fiscal 2023
6 · The paper itself

Abstract

Androgenetic alopecia (AGA) is marked by the progressive miniaturization of hair follicles (HFs) and hair thinning, driven by a decline in the progenitor cells critical for hair regeneration. Despite this, the mechanisms responsible for progenitor cell depletion remain largely unclear. To investigate transcriptional alterations in the progenitor cell regions of AGA patients while maintaining the spatial tissue context, we employed the GeoMX Digital Spatial Profiling (DSP) platform, which enables a precise comparison with healthy controls. Our analysis revealed the significant upregulation of genes associated with extracellular matrix (ECM) organization and the epithelial-mesenchymal transition (EMT), including

Indexed as

AlopeciaStem CellsTranscriptomeAdultEpithelial-Mesenchymal TransitionExtracellular MatrixFemaleFibronectinsGene Expression ProfilingHair FollicleHumansMaleMiddle AgedNuclear ProteinsTransforming Growth Factor beta2Twist-Related Protein 1FibronectinsFN1 protein, humanNuclear ProteinsTGFB2 protein, humanTransforming Growth Factor beta2TWIST1 protein, humanTwist-Related Protein 1androgenetic alopeciaepithelial–mesenchymal transitionextracellular matrixprogenitor cell lossspatial transcriptomics

Identifiers

PMID40565255
PMCPMC12193697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.