Evidence map›Paper›PMID 40565206›Full record

ArticleInternational journal of molecular sciences2025

Specific Heat-Killed Lactic Acid Bacteria Enhance Mucosal Aminopeptidase N Activity in the Small Intestine of Aged Mice.

Takeshi Tsuruta, Mami Wakisaka, Takumi Watanabe, Aoi Nishijima, Akihito Ikeda, Mao Teraoka, Tianyang Wang, Kuiyi Chen, Naoki Nishino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effect of Heat-KilledLife (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takeshi TsurutaFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Mami WakisakaFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Takumi WatanabeBio-Lab Co., Ltd., Hidaka-shi 350-1249, Japan.ORCID 0000-0002-4607-0747
Aoi NishijimaFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Akihito IkedaFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Mao TeraokaFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Tianyang WangFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Kuiyi ChenFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.
Naoki NishinoFaculty of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 7008530, Japan.ORCID 0000-0001-6105-8124

Funding

Japan Society for the Promotion of Science 23K10959
6 · The paper itself

Abstract

Aminopeptidase N (APN), an enzyme expressed in the small intestinal mucosa, is involved in dietary protein digestion. Previous studies have shown that oral administration of fermented milk containing lactic acid bacteria (LAB) enhances mucosal APN activity in young mice. This study aimed to investigate whether LAB strains stimulate mucosal APN activity in aged mice and to evaluate its relevance to age-related changes in body composition. The underlying molecular mechanisms were also explored in vitro. Experiment 1: Aged C57BL/6J mice were fed diets supplemented with heat-killed LAB strains-

Indexed as

AgingCD13 AntigensIntestinal MucosaIntestine, SmallLactobacillalesAnimalsCell LineHot TemperatureMaleMiceMice, Inbred C57BLProbioticsCD13 Antigensagingaminopeptidase Nbone metabolismlactic acid bacteriasmall intestine

Identifiers

PMID40565206
PMCPMC12193318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.