Evidence map›Paper›PMID 40565153›Full record

ArticleInternational journal of molecular sciences2025

Unique Structural Features Relate to Evolutionary Adaptation of Cytochrome P450 in the Abyssal Zone.

Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, George Minasov, Jared V Goldstone, Steven L Kelly, John J Stegeman, Galina I Lepesheva

Abstract read
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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tatiana Y HargroveDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
David C LambFaculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, UK.
Zdzislaw WawrzakNorthwestern Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.
George MinasovDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jared V GoldstoneDepartment of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.
Steven L KellyFaculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, UK.
John J StegemanDepartment of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA.
Galina I LepeshevaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.ORCID 0000-0002-6975-1131

Funding

Structural requirements for sterol 14α-demethylasesR35GM151876 · NIGMS · VANDERBILT UNIVERSITY · PI Galina I Lepesheva · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM151876
6 · The paper itself

Abstract

Cytochromes P450 (CYPs) form one of the largest enzyme superfamilies, with similar structural folds yet biological functions varying from synthesis of physiologically essential compounds to metabolism of myriad xenobiotics. Sterol 14α-demethylases (CYP51s) represent a very special P450 family, regarded as a possible evolutionary progenitor for all currently existing P450s. In metazoans CYP51 is critical for the biosynthesis of sterols including cholesterol. Here we determined the crystal structures of ligand-free CYP51s from the abyssal fish

Indexed as

Cytochrome P-450 Enzyme SystemEvolution, MolecularFishesSterol 14-DemethylaseAmino Acid SequenceAnimalsCrystallography, X-RayHumansModels, MolecularPhylogenyProtein ConformationSubstrate SpecificityCytochrome P-450 Enzyme SystemSterol 14-Demethylasebiological membranesconformational flexibilitycrystal structurecytochrome P450evolutionary adaptationsterol 14α-demethylase (CYP51)structure–function

Identifiers

PMID40565153
PMCPMC12192976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.