ArticleInternational journal of molecular sciences2025
Three Dimensionally Printed Octacalcium Phosphate via Binder Jetting for Use in Bone Grafting Applications.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Bone regenerative efficacy of binder-jet fabricated hydroxyapatite granules with and without biomimetic octacalcium phosphate-coated modification in a rat critical-sized calvarial defect model.Regenerative biomaterials · 2026Article
- Fabrication and evaluation of PLA/CPP/GO composite scaffolds: the role of graphene oxide content in regulating properties.RSC advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This study investigates the fabrication and bioactivity of monophasic octacalcium phosphate (OCP) constructs using 3D-printed calcium sulfate precursors. A single-step and a two-step process were employed, transforming calcium sulfate into OCP through a controlled phase transformation in a disodium hydrogen phosphate solution. The results revealed that a single-step process for OCP conversion in 3D printed samples was unsuccessful due to incomplete transformation and the formation of intermediate phases such as brushite and monetite. In contrast, the two-step process enabled the efficient production of monophasic OCP in a shorter timeframe. The converted OCP samples exhibited a compressive strength of 7.65 ± 0.46 MPa and a contact angle of zero, indicating adequate handling strength and high wettability. The resorbability of 3D-printed OCP in simulated body fluid (SBF) was evaluated, showing weight loss through gradual dissolution accompanied by the release of calcium and phosphorus ions, followed by the consumption of these ions for reprecipitation back into OCP without direct transformation into hydroxyapatite (HA). Biocompatibility and bioactivity testing demonstrated high cell viability (96.67 ± 0.18%) using the MTT assay, indicating that the 3D-printed OCP was not cytotoxic. Alamar blue and alkaline phosphatase (ALP) activity assay showed that 3D-printed OCP supported preosteoblast proliferation and osteogenic differentiation.
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Registered trials
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