Evidence map›Paper›PMID 40564973›Full record

ReviewInternational journal of molecular sciences2025

Harnessing Transient Expression Systems with Plant Viral Vectors for the Production of Biopharmaceuticals in

Sayed Abdul Akher, Kevin Yueju Wang, Kylie Hall, Oluwaseyi Setonji Hunpatin, Muhammad Shan, Zenglin Zhang, Yongfeng Guo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Plant-Based Systems for Producing Therapeutic Proteins: Current Status and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Nicotiana benthamiana Biofactory.Plant biotechnology journal · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sayed Abdul AkherTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.ORCID 0000-0002-0710-7746
Kevin Yueju WangTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.ORCID 0009-0006-3324-4505
Kylie HallDivision of Math and Natural Sciences, University of Pikeville, Pikeville, KY 41051, USA.
Oluwaseyi Setonji HunpatinTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.ORCID 0009-0007-8078-5758
Muhammad ShanTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.ORCID 0000-0001-5146-7717
Zenglin ZhangTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.
Yongfeng GuoTobacco Research Institute, Chinese Academy of Agricultural Sciences, Qingdao 266101, China.ORCID 0000-0002-2033-7386

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
Key R&D Program of Shandong Province 2022SFGC0102NIGMS NIH HHS P20 GM103436the Agricultural Science and Technology Innovation Program ASTIP-TRIC02the National Institute of General Medical Sciences, National Institutes of Health. P20GM103436-24 (KY INBRE)
6 · The paper itself

Abstract

Plant Molecular Farming (PMF) capitalizes on the unique properties of plants as bioreactors to efficiently produce valuable proteins, pharmaceuticals, and enzymes. This review emphasizes the critical role of transient expression systems, particularly in

Indexed as

Genetic VectorsNicotianaRecombinant ProteinsBioreactorsCOVID-19Gene EditingHumansMolecular FarmingPlants, Genetically ModifiedSARS-CoV-2Recombinant Proteinsbiopharmaceuticalscontrolled environment agricultureN. benthamianaplant molecular farmingrecombinant proteinstransient expression

Identifiers

PMID40564973
PMCPMC12193647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.