Evidence map›Paper›PMID 40564971›Full record

ArticleInternational journal of molecular sciences2025

Omega-3 Fatty Acids Mitigate Long-Lasting Disruption of the Endocannabinoid System in the Adult Mouse Hippocampus Following Adolescent Binge Drinking.

Maitane Serrano, Miquel Saumell-Esnaola, Garazi Ocerin, Gontzal García Del Caño, Edgar Soria-Gómez, Amaia Mimenza, Nagore Puente, Itziar Bonilla-Del Río, Almudena Ramos-Uriarte, Leire Reguero and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maitane SerranoDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0002-8296-9231
Miquel Saumell-EsnaolaDepartment of Pharmacology, Faculty of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0003-0703-162X
Garazi OcerinDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0009-0009-5021-0413
Gontzal García Del CañoBioaraba, Neurofarmacología Celular y Molecular, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-7098-0986
Edgar Soria-GómezDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0002-1361-5915
Amaia MimenzaDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Nagore PuenteDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Itziar Bonilla-Del RíoDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Almudena Ramos-UriarteDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Leire RegueroDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Brian R ChristieDivision of Medical Sciences and Institute for Aging and Lifelong Health, University of Victoria, Victoria, BC V8P 5C2, Canada.ORCID 0000-0002-6830-0160
Fernando Rodríguez de FonsecaRed de Investigación en Atención Primaria de Adicciones (RIAPAD), ISCIII, 28029 Madrid, Spain.ORCID 0000-0002-4516-5795
Marta Rodríguez-AriasRed de Investigación en Atención Primaria de Adicciones (RIAPAD), ISCIII, 28029 Madrid, Spain.ORCID 0000-0002-1121-8879
Inmaculada GerrikagoitiaDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.
Pedro GrandesDepartment of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, 48940 Leioa, Spain.ORCID 0000-0003-3947-4230

Funding

Instituto de Salud Carlos III RD21/0009/0003, RD21/0009/0005, RD21/0009/0006Instituto de Salud Carlos III RD24/0003/0004, RD24/0003/0012, RD24/0003/0027Ministry of Science and Innovation PID2022-138266NB-I00The Basque Government IT1620-22
6 · The paper itself

Abstract

Adolescent binge drinking has lasting behavioral consequences by disrupting the endocannabinoid system (ECS) and depleting brain omega-3. The natural accumulation of omega-3 fatty acids in cell membranes is crucial for maintaining the membrane structure, supporting interactions with the ECS, and restoring synaptic plasticity and cognition impaired by prenatal ethanol (EtOH) exposure. However, it remains unclear whether omega-3 supplementation can mitigate the long-term effects on the ECS, endocannabinoid-dependent synaptic plasticity, and cognition following adolescent binge drinking. Here, we demonstrated that omega-3 supplementation during EtOH withdrawal increases CB1 receptors in hippocampal presynaptic terminals of male mice, along with the recovery of receptor-stimulated [

Indexed as

Binge DrinkingEndocannabinoidsFatty Acids, Omega-3HippocampusAnimalsArachidonic AcidsEthanolLong-Term PotentiationMaleMaze LearningMiceMice, Inbred C57BLNeuronal PlasticityPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1Receptors, N-Methyl-D-AspartateanandamideArachidonic AcidsEndocannabinoidsEthanolFatty Acids, Omega-3Polyunsaturated AlkamidesReceptor, Cannabinoid, CB1Receptors, N-Methyl-D-AspartateTRPV1 protein, mouseTRPV Cation ChannelsalcoholCB1 receptorhippocampusmemorypolyunsaturated fatty acidssynaptic plasticity

Identifiers

PMID40564971
PMCPMC12192632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.