Evidence map›Paper›PMID 40564958›Full record

ArticleInternational journal of molecular sciences2025

Gene Copy Number Dictates Extracellular Vesicle Cargo.

Sumeet Poudel, Zhiyong He, Jerilyn Izac, Lili Wang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sumeet PoudelNational Institute of Standards and Technology (NIST), Gaithersburg, MD 20817, USA.ORCID 0009-0006-7617-9838
Zhiyong HeNational Institute of Standards and Technology (NIST), Gaithersburg, MD 20817, USA.ORCID 0009-0002-4650-2826
Jerilyn IzacNational Institute of Standards and Technology (NIST), Gaithersburg, MD 20817, USA.ORCID 0000-0003-1762-4680
Lili WangNational Institute of Standards and Technology (NIST), Gaithersburg, MD 20817, USA.ORCID 0000-0003-2456-898X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membrane-surrounded vesicles that carry heterogeneous cellular components, including proteins, nucleic acids, lipids, and metabolites. EVs' intravesicular and surface contents possess many biomarkers of physiological and pathological importance. Because of the heterogeneous cargo, EVs can mediate local and distal cell-cell communication. However, the way in which the genome signature regulates EV cargo has not been well studied. This study aimed to understand how genetics impact EV cargo loading. EVs were isolated from vector copy number cells with a fluorescent reporter (

Indexed as

Breast NeoplasmsExtracellular VesiclesGene DosageCell Line, TumorErb-b2 Receptor Tyrosine KinasesFemaleGenes, ReporterGreen Fluorescent ProteinsHumansERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGreen Fluorescent ProteinsEVEV biologyEV cargoEV Imaging Flow Cytometry AnalysisEV protein loadingEV RNA loading

Identifiers

PMID40564958
PMCPMC12192956

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.