Evidence map›Paper›PMID 40564895›Full record

ArticleInternational journal of molecular sciences2025

Assessment of White Matter Changes Using Quantitative T1ρ Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI).

Dina Moazamian, Shengwen Xie, Jiyo S Athertya, Qingbo Tang, Roland R Lee, Eric Y Chang, Jeffrey M Tomlin, Catherine E Johnson, Jiang Du, Yajun Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dina MoazamianDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.ORCID 0000-0002-8815-4535
Shengwen XieDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.
Jiyo S AthertyaDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.ORCID 0000-0002-0866-1052
Qingbo TangDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.
Roland R LeeDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.ORCID 0000-0001-5628-4151
Eric Y ChangDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.ORCID 0000-0003-3633-5630
Jeffrey M TomlinDepartment of Neurological Surgery, University of California, San Diego, CA 92093, USA.
Catherine E JohnsonDepartment of Explosive Engineering, Missouri University of Science and Technology, Rolla, MO 65409, USA.ORCID 0000-0002-0670-8179
Jiang DuDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.ORCID 0000-0002-9203-2450
Yajun MaDepartment of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's DiseaseRF1AG075717 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2022 to 2022
$2.3M
Whole Head Magnetoencephalography (MEG) SystemS10OD034302 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, ROLAND ROBERT · 2023 to 2023
$2.0M
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's DiseaseR01AG075717 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jiang Du · 2025 to 2026
$1.3M
Comparison of direct and indirect magnetic resonance imaging of myelin in Alzheimer's diseaseF32AG082458 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ATHERTYA, JIYO S · 2023 to 2025
$256k
CSRD VA I01 CX002211Jiang Du I01CX002211Jiang Du RF1AG075717Jiyo S. Athertya F32AG082458NIAMS NIH HHS R01 AR079484NIA NIH HHS F32 AG082458NIA NIH HHS R01 AG075717NIA NIH HHS RF1 AG075717NIH HHS S10 OD034302Yajun Ma R01AR079484
6 · The paper itself

Abstract

Blast-induced mild traumatic brain injury (mTBI) occurs when shock waves travel through blood vessels and cerebrospinal fluid, leading to cerebral demyelination, which results in cognitive impairments and neuropsychiatric issues that impact quality of life. This study aims to evaluate myelin changes in white matter in mice with mTBI induced by an open-field low-intensity blast (LIB) using a newly implemented 3D adiabatic T1ρ prepared fast spin echo (Adiab-T1ρ-FSE) sequence for quantitative T1ρ MRI mapping. Thirty male C57BL/6 mice, including 15 mTBI and 15 sham controls, were scanned on a 3T Bruker MRI scanner. Luxol fast blue (LFB) staining was performed to assess myelin content differences between the mTBI and sham control groups. A significantly higher T1ρ value in the medial corpus callosum (MCC) was found in mTBI mice compared to controls (126.8 ± 2.5 ms vs. 129.8 ± 2.5 ms;

Indexed as

Blast InjuriesBrain ConcussionMagnetic Resonance ImagingWhite MatterAnimalsCorpus CallosumDisease Models, AnimalMaleMiceMice, Inbred C57BLMyelin SheathMRImTBImyelin lossopen-field LIBT1ρ

Identifiers

PMID40564895
PMCPMC12193592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.