ArticleBioengineering (Basel, Switzerland)2025
A Miniaturized Implantable Telemetry Biosensor for the Long-Term Dual-Modality Monitoring of Core Temperature and Locomotor Activity.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Implantable telemetry biosensors have become powerful tools for continuous physiological monitoring with minimal animal perturbation. However, commercially available implants are relatively oversized for small animals such as mice and have limited transmission range, leading to concerns about animal welfare, experiment scenarios, and the reliability of the data. In this study, we designed a telemetry system that tracks the animals' body temperature and locomotor activity in real time. The implant integrates a temperature sensor with a 3-axis accelerometer and is capable of wirelessly transmitting data over a 40 m mesh network. The implant's temperature performance was evaluated in bench tests, showing a response rate of 0.2 °C/s, drift ≤ 0.03 °C within 31 days, and a standard deviation of 0.035 °C across three identically designed implants. Meanwhile, the in vivo implant's locomotion recordings showed strong agreement with computer vision analysis with a correlation coefficient of r = 0.95 (
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