Effects of Physiological Loading from Patient-Derived Activities of Daily Living on the Wear of Metal-on-Polymer Total Hip Replacements.

The current pre-clinical testing standards for total hip replacements (THRs), ISO standards, use simplified loading waveforms that do not fully replicate real-world biomechanics. These standards provide a benchmark of data that may not accurately predict in vivo wear, necessitating the evaluation of physiologically relevant loading conditions. Previous studies have incorporated activities of daily living (ADLs) such as walking, jogging and stair negotiation into wear simulations. However, these studies primarily used simplified adaptations that increased axial forces and applied accelerated sinusoidal waveforms, rather than fully replicating the complex kinematics experienced by THR patients. To address this gap, this study applied patient-derived ADL profiles-jogging and stair negotiation-using a three-station hip simulator, obtained through 3D motion analysis of total hip arthroplasty patients, processed via a musculoskeletal multibody modelling approach to derive realistic hip contact forces (HCFs). The results indicate that jogging significantly increased wear rates compared to the ISO walking gait waveform, with wear increasing from 15.24 ± 0.55 to 28.68 ± 0.87 mm