Evidence map›Paper›PMID 40564385›Full record

ArticleBioengineering (Basel, Switzerland)2025

Wheat Bran Polymer Scaffolds: Supporting Triple-Negative Breast Cancer Cell Growth and Development.

Abulquasem Rayat Hossain, Md Sultan Mahmud, Kaydee Koistinen, George Davisson, Brooke Roeges, Hayle Boechler, Md Abdur Rahim Badsha, Md Rakib Hasan Khan, Michael Kjelland, Dorsa Fereydoonpour and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Abulquasem Rayat HossainDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA.
Md Sultan MahmudSpring Wheat Quality, North Dakota State University, Fargo, ND 58108, USA.ORCID 0000-0002-8558-7669
Kaydee KoistinenDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.
George DavissonDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.
Brooke RoegesCollege of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A5, Canada.
Hayle BoechlerDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.
Md Abdur Rahim BadshaDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.ORCID 0009-0000-5305-1467
Md Rakib Hasan KhanBiomedical Engineering, North Dakota State University, Fargo, ND 58108, USA.
Michael KjellandDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.ORCID 0000-0002-6162-1578
Dorsa FereydoonpourDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA.
Mohiuddin QuadirBiomedical Engineering, North Dakota State University, Fargo, ND 58108, USA.
Sanku MallikDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58108, USA.
Khwaja HossainDivision of Science and Mathematics, Mayville State University, Mayville, ND 58257, USA.ORCID 0000-0002-2001-4499

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
NIGMS NIH HHS U54 GM128729NSF EPSCoR Track-1 ND-ACES 1946202
6 · The paper itself

Abstract

Arabinoxylans (AX) are functional biopolymers, the main non-starch polysaccharides in cereals and other plants. AX is composed of xylose and arabinose, and the ester-linkage of ferulic acid to arabinose confers its bioactive properties. The backbone of AX resembles that of glycosaminoglycans, a major component of the human extracellular matrix. This study explores the potential of wheat bran AX-based scaffolds as a novel platform for the growth and development of triple-negative breast cancer (TNBC) cells, an aggressive form of breast cancer. Importantly, patients face the worst prognosis due to the stemness of the TNBC cells and the formation of hypoxic cell clumps. Wheat bran constitutes 15-25% of the byproducts after milling and adds limited economic value. We have extracted AX from wheat bran (WBAX) and developed soft scaffolds with Na-alginate. The scaffolds were seeded with the triple-negative breast cancer cell line MDA-MB-231. Over 21 days, cell growth and development, cell migration within the hydrogels, and the formation of hypoxic regions within cell clumps were observed. These findings suggest that WBAX-based scaffolds provide a conducive environment for TNBC cell proliferation and development, offering a promising avenue for further research into cancer cell biology and potential therapeutic applications.

Indexed as

arabinoxylanbreast cancerhypoxiaMDA-MB-231 cell linesscaffoldsspheroidwheat bran

Identifiers

PMID40564385
PMCPMC12189314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.