Evidence map›Paper›PMID 40564265›Full record

ReviewAnimals : an open access journal from MDPI2025

Bacteriophages as Potential Anti-Pathogenic Agents for Intestinal Health of Weaned Piglets in the Post-Antibiotic Era: An Updated Review.

Jun Chen, Jiajun Han, Zheng Yang, Wenyue Zhou, Yuyong He, Xingping Chen, Xin Li, Tiande Zou, Jinming You

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun ChenJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0001-5037-3479
Jiajun HanJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Zheng YangJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Wenyue ZhouJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Yuyong HeJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Xingping ChenJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.ORCID 0000-0002-5651-4014
Xin LiJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Tiande ZouJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.
Jinming YouJiangxi Province Key Laboratory of Animal Nutrition and Feed, Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry, Jiangxi Agricultural University, Nanchang 330045, China.

Funding

Jiangxi Provincial Cultivation Program for Academic and Technical Leaders of Major Subjects No. 20213BCJ22005Key Research and Development Program of Jiangxi Province No. 20223BBF61018Key Research and Development Program of Jiangxi Province No. 20224BBF61029National Natural Science Foundation of China No. 32160806
6 · The paper itself

Abstract

backgroundThe use of in-feed antibiotics was banned in numerous countries within the animal production industry as a result of the emergence of antibiotic-resistant bacteria and the presence of residual antibiotics. Bacteriophages, which are viruses that infect host bacterial cells, are considered the natural predators of bacteria. Over the past two decades, bacteriophages have garnered increasing attention for their potential in controlling pathogenic bacteria in weaned piglets.

aimsThe aim of this overview was to update the progress of bacteriophage application in weaned piglets.

methodsFor the section on bacteriophage application in weaned piglets, a systematic search was performed to identify relevant articles published before June 2025 in databases such as Web of Science.

resultsIn this review, we provide a brief overview of bacteriophages, followed by a summary of the isolation of specific bacteriophages in weaned piglets. In addition, we have summarized the application progress of bacteriophages in weaned piglets, including the effects of oral administration or dietary supplementation with bacteriophages on growth performance, diarrhea characteristics, intestinal morphology, intestinal pH, nutrient digestibility, inflammatory response, intestinal barrier function, and intestinal microecology.

conclusionsThis updated overview novelly highlights the potential of bacteriophages as anti-pathogenic agents in mitigating infections caused by pathogenic bacteria in weaned piglets. This review could provide a scientific basis for controlling pathogenic bacteria infections in weaned piglets in the post-antibiotic era.

Indexed as

antibiotic resistanceanti-pathogenic agentsbacteriophagesdiarrheagrowth performanceintestinal healthpost-antibiotic eraswine industryweaned piglets

Identifiers

PMID40564265
PMCPMC12189532

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.