Evidence map›Paper›PMID 40564186›Full record

ReviewBiomedicines2025

Tubal Ectopic Pregnancy: From Diagnosis to Treatment.

Dimitrios Papageorgiou, Ioakeim Sapantzoglou, Ioannis Prokopakis, Eleftherios Zachariou

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dimitrios PapageorgiouDepartment of Gynecology, Athens Naval and Veterans Hospital, 115 21 Athens, Greece.ORCID 0000-0003-0160-7755
Ioakeim Sapantzoglou1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.
Ioannis Prokopakis1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 106 79 Athens, Greece.ORCID 0009-0009-3853-8352
Eleftherios Zachariou1st Gynecology Department, Metropolitan General Hospital, 142 32 Athens, Greece.ORCID 0000-0001-8754-3048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most frequent form of ectopic pregnancy, known as tubal pregnancy, leads to a dangerous situation where the fertilized ovum implants inside a fallopian tube, which can result in tubal rupture and severe bleeding. The purpose of this narrative review is to evaluate all existing data regarding epidemiology, risk factors, pathophysiology, clinical presentation, diagnosis, and management of tubal ectopic pregnancy in order to provide a comprehensive understanding of this common yet difficult clinical condition. Prior ectopic pregnancy, together with tubal pathology and assisted reproduction, represent the main risk factors for this condition. The diagnosis relies on serial β-hCG tests combined with transvaginal ultrasonography, but laparoscopy serves as the diagnostic tool for cases with uncertain results. The treatment plan depends on the fallopian tube integrity, along with the patient's hemodynamic condition. Patients with unruptured pregnancies who are hemodynamically stable receive methotrexate treatment as the preferred option, but surgical intervention with salpingectomy or salpingostomy becomes necessary in case of tubal rupture or when medical treatment fails. The development of laparoscopic procedures has led to better results and improved possibilities for fertility preservation. The psychological effects on patients require both counseling and follow-up care. Early detection, along with personalized management, helps decrease maternal complications and optimize reproductive outcomes.

Indexed as

diagnostic laparoscopyectopic pregnancyexpectant managementmethotrexatesalpingectomysalpingostomytubal pregnancyβ-hCG

Identifiers

PMID40564186
PMCPMC12191334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.