Evidence map›Paper›PMID 40564168›Full record

ArticleBiomedicines2025

Improved Translational Relevance of In Vitro Fibrosis Models by Integrating IOX2-Mediated Hypoxia-Mimicking Pathways.

Manuel A González Hernández, Jennifer Venhorst, Lars Verschuren, Karin Toet, Martien P M Caspers, Martine C Morrison, Beatrice Coornaert, Gerard J P van Westen, Roeland Hanemaaijer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manuel A González HernándezDrug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Jennifer VenhorstUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.ORCID 0000-0001-6383-9776
Lars VerschurenUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.ORCID 0000-0002-7847-9037
Karin ToetUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.
Martien P M CaspersUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.ORCID 0000-0002-0248-4008
Martine C MorrisonUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.ORCID 0000-0003-4996-943X
Beatrice CoornaertGalapagos NV, Generaal de Wittelaan L11 A3, 2800 Mechelen, Belgium.
Gerard J P van WestenDrug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands.ORCID 0000-0003-0717-1817
Roeland HanemaaijerUnit Healthy Living and Work, The Netherlands Organisation for Applied Scientific Research, TNO, Sylviusweg 71, 2333 BE Leiden, The Netherlands.

Funding

Province Zuid-Holland DOS-2020-0008054
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

fibrosis mechanismshypoxialiver fibrosispreclinical models

Identifiers

PMID40564168
PMCPMC12190251

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.