Evidence map›Paper›PMID 40564043›Full record

ArticleBiomedicines2025

Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation.

Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A Dyment, Yu Yamaguchi, David W Rowe, Gengyun Le-Chan, Sunny S K Chan and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Cartilage-SpecificBiomedicines · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yingcui LiDepartment of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA.ORCID 0000-0002-7425-7162
Alexander TressDepartment of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA.ORCID 0009-0009-3745-0359
Peter MayeCenter for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06032, USA.
Kemar EdwardsDepartment of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA.ORCID 0009-0001-6347-9587
Asiona FindletarDepartment of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA.
Nathaniel A DymentDepartment of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yu YamaguchiHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-0098-281X
David W RoweCenter for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06032, USA.
Gengyun Le-ChanDepartment of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA.ORCID 0009-0001-6056-484X
Sunny S K ChanDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-1432-7381
Kevin W-H LoDepartment of Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA.

Funding

Skeletal Phenotyping of Heterozygotes from IMPC Embryonic Lethal LinesR01HD098636 · NICHD · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAYE, PETER, ROWE, DAVID W. · 2019 to 2023
$2.8M
NICHD NIH HHS R01 HD098636
6 · The paper itself

Abstract

Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of Hyaluronan Synthase 2 (

Indexed as

cartilage homeostasishyaluronanhyaluronan synthase 2 (Has2)limb developmentsynovial joint formation

Identifiers

PMID40564043
PMCPMC12189151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.