Evidence map›Paper›PMID 40564017›Full record

ReviewBiomedicines2025

Molecular Biomarkers of Glioma.

Punsasi Rajakaruna, Stella Rios, Hana Elnahas, Ashley Villanueva, David Uribe, Sophia Leslie, Walaa A Abbas, Larissa Barroso, Stephanie Oyervides, Michael Persans and 2 more

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Multi-Omics Integration for Advancing Glioma Precision Medicine.Annals of clinical and translational neurology · 2026
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Punsasi RajakarunaSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.
Stella RiosSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0000-0003-4184-7526
Hana ElnahasSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0009-0005-1255-1621
Ashley VillanuevaSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.
David UribeSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.
Sophia LeslieSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0009-0003-7940-316X
Walaa A AbbasSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0000-0003-4598-4018
Larissa BarrosoSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.
Stephanie OyervidesSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0009-0008-1500-0157
Michael PersansSchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.
Wendy Innis-WhitehouseBurrell College of Osteopathic Medicine, 3501 Arrowhead Dr, Las Cruces, NM 88001, USA.
Megan KenirySchool of Integrative Biological and Chemical Sciences, The University of Texas Rio Grande Valley, 1201 W. University Dr., Edinburg, TX 78539, USA.ORCID 0000-0002-4952-3545

Funding

Investigating fundamental signal transduction mechanisms impacted by FOXO transcription factors on NOTCH and JAK/STAT Pathways in stem cell contextsR16GM153687 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI Megan E Keniry · 2024 to 2026
$444k
NIGMS NIH HHS R16 GM153687NIH, NIGMS 1R16GM153687-01
6 · The paper itself

Abstract

In this review, we discuss how mutations in glioma are associated with prognosis and treatment efficacy. A fascinating characteristic of glioma and all cancers is that while common growth and developmental pathways are altered, the characteristic mutations are distinct depending on the specific type of tumor with concomitant prognoses. Next-generation sequencing, precision medicine, and artificial intelligence are boosting the employment of molecular biomarkers in cancer diagnosis and treatment. Understanding the biological underpinnings of distinct mutations on critical signaling pathways is crucial for developing novel therapies for glioma.

Indexed as

astrocytomaglioblastomagliomaIDHoligodendroglioma

Identifiers

PMID40564017
PMCPMC12189432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.