Effect of Maternal Hyperglycemia on Fetal Pancreatic Islet Development.

Carina Pereira Dias, Michel Raony Teixeira Paiva de Moraes, Fernanda Angela Correia Barrence, Camila Stephanie Balbino da Silva, Basilio Smuckzec, Fernanda Ortis, Telma Maria Tenório Zorn

Abstract read

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In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carina Pereira DiasLaboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Cidade Universitária, São Paulo 05508-000, Brazil.

Michel Raony Teixeira Paiva de MoraesLaboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Cidade Universitária, São Paulo 05508-000, Brazil.

Fernanda Angela Correia BarrenceLaboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Cidade Universitária, São Paulo 05508-000, Brazil.

Camila Stephanie Balbino da SilvaLaboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Cidade Universitária, São Paulo 05508-000, Brazil.

Basilio SmuckzecTumor Biology Laboratory, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária, São Paulo 05508-000, Brazil.ORCID 0009-0001-4577-6393

Fernanda OrtisMolecular Mechanism of Beta Cell Death Laboratory, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, Cidade Universitária, São Paulo 05508-000, Brazil.

Telma Maria Tenório ZornLaboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, Cidade Universitária, São Paulo 05508-000, Brazil.

Funding

São Paulo Research Foundation (FAPESP) 13/16922-4.

6 · The paper itself

Abstract

Hyperglycemia during fetal development disturbs extracellular matrix (ECM) synthesis and deposition patterns, which disrupts organogenesis and adult organ function. Although the ECM cooperates in pancreas development, little is known about the effects of hyperglycemia on the pancreatic ECM during development. This study investigates the effect of severe maternal hyperglycemia on ECM composition and endocrine pancreas development in E19.0 mouse fetuses. Deposition patterns of pan-laminin, laminin (alpha 1 and gamma 1 chains) and integrin alpha 3 were evaluated by immunostaining. The proliferative index of islet cells and alpha and beta cell distribution were evaluated by PCNA, glucagon and insulin immunostaining, respectively.

Indexed as

diabetes mellitusextracellular matrixfetal reprogramming

Identifiers

PMID40563978

DOI10.3390/biology14060728

PMCPMC12189325

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.