Evidence map›Paper›PMID 40563927›Full record

ArticleBiology2025

Integrative Single-Cell Transcriptomics and Network Modeling Reveal Modular Regulators of Sheep Zygotic Genome Activation.

Xiaopeng Li, Peng Niu, Kai Hu, Xueyan Wang, Fei Huang, Pengyan Song, Qinghua Gao, Di Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaopeng LiCollege of Animal Science and Technology, Tarim University, Alar 843300, China.ORCID 0000-0003-0796-0795
Peng NiuCollege of Life Science and Technology, Tarim University, Alar 843300, China.ORCID 0000-0002-1710-4805
Kai HuCollege of Animal Science and Technology, Tarim University, Alar 843300, China.
Xueyan WangCollege of Animal Science and Technology, Tarim University, Alar 843300, China.
Fei HuangCollege of Life Science and Technology, Tarim University, Alar 843300, China.ORCID 0000-0002-2611-0617
Pengyan SongCollege of Animal Science and Technology, Tarim University, Alar 843300, China.
Qinghua GaoCollege of Animal Science and Technology, Tarim University, Alar 843300, China.
Di FangCollege of Animal Science and Technology, Tarim University, Alar 843300, China.

Funding

National Natural Science Foundation of China 32402760Xinjiang Tianchi Doctoral Introduction Plan Project None
6 · The paper itself

Abstract

Zygotic genome activation (ZGA) marks the critical transition from reliance on maternal transcripts to the initiation of embryonic transcription early in development. Despite extensive characterization in model species, the regulatory framework of ZGA in sheep remains poorly defined. Here, we applied single-cell RNA sequencing (Smart-seq2) to in vivo- and in vitro-derived sheep embryos at the 8-, 16-, and 32-cell stages. Differential expression analysis revealed 114, 1628, and 1465 genes altered in the 8- vs. 16-, 16- vs. 32-, and 8- vs. 32-cell transitions, respectively, with the core pluripotency factors

Indexed as

Louvain algorithmsheep embryossingle cell transcriptomicsWGCNAzygotic genome activation

Identifiers

PMID40563927
PMCPMC12189800

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.