Evidence map›Paper›PMID 40563830›Full record

ArticleBrain sciences2025

Geographic Distribution and Future Projections of Mild Cognitive Impairment and Dementia in Greece: Analysis from 1991 to 2050.

Themis P Exarchos, Konstantina Skolariki, Vasiliki Mahairaki, Constantine G Lyketsos, Panagiotis Vlamos, Nikolaos Scarmeas, Efthimios Dardiotis, On Behalf Of The Hellenic Initiative Against Alzheimer's Disease Hiaad

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Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Personal and Family Perspectives Regarding Neurodegenerative Disorder Risk.Journal of community medicine & public health · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Themis P ExarchosBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49132 Corfu, Greece.
Konstantina SkolarikiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vasiliki MahairakiDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Constantine G LyketsosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3827-4720
Panagiotis VlamosBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49132 Corfu, Greece.ORCID 0000-0003-0053-7847
Nikolaos ScarmeasFirst Department of Neurology, Aiginition Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-6453-8908
Efthimios DardiotisDepartment of Neurology, Medical School, University of Thessaly, 41334 Larisa, Greece.ORCID 0000-0003-2957-641X
On Behalf Of The Hellenic Initiative Against Alzheimer's Disease Hiaad

Funding

This work was carried out within the framework of the Action 'Flagship Research Projects in challenging interdisciplinary sectors with practical applications in Greek industry', implemented through the National Recovery and Resilience Plan Greece 2.0 and project code: TAEDR-0535850
6 · The paper itself

Abstract

backgroundGreece is among the fastest-aging countries globally, with one of the highest proportions of elderly individuals. As a result, the prevalence of mild cognitive impairment (MCI) and dementia is among the highest in Europe. The distribution of affected individuals varies considerably across different regions of the country.

methodWe estimated the number of people living with MCI or dementia in Greece and visualized these estimates using heatmaps by regions for four census years: 1991, 2001, 2011, and 2023 (the 2023 census was delayed due to the COVID-19 pandemic). Age- and sex-specific prevalence rates of MCI and dementia were obtained from the Hellenic Longitudinal Investigation of Aging and Diet. These prevalence rates were then applied to population data from each census to estimate the number of affected individuals per region.

resultsThere was a consistent increase in the number of people living with MCI, rising from 177,898 in 1991 to 311,189 in 2023. Dementia cases increased from 103,535 in 1991 to 206,939 in 2023. Projections based on future census data for 2035 and 2050 suggest that the number of people with MCI will reach 375,000 and 440,000, respectively, while dementia cases will increase to 250,000 in 2035 and 310,000 in 2050.

conclusionGiven that each person with dementia typically requires care from at least two caregivers over time, these projections highlight the profound impact the dementia epidemic will have on Greece. The heatmaps developed in this study can serve as valuable tools for policymakers in designing and implementing clinical care programs tailored to the needs of each region based on the projected burden of disease.

Indexed as

dementiadistribution heatmapsfuture projectionmild cognitive impairment

Identifiers

PMID40563830
PMCPMC12191139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.