Evidence map›Paper›PMID 40563819›Full record

ReviewBrain sciences2025

Understanding the Radiobiology of Central Nervous System Diseases in the Golden Age of Radiosurgery-Does It Matter?

Fred C Lam, John Byun, Santosh Guru, Deyaldeen AbuReesh, Yusuke S Hori, Elham Rahimy, Erqi Liu Pollom, Scott Soltys, David J Park, Steven D Chang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fred C LamDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
John ByunDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Santosh GuruDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Deyaldeen AbuReeshDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Yusuke S HoriDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Elham RahimyDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Erqi Liu PollomDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Scott SoltysDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-5360-7063
David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.ORCID 0000-0002-9858-2592
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94304, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereotactic radiosurgery (SRS) deploys image-guidance to deliver multiple beams of highly focused ionizing radiation to tightly conformed anatomical targets, leading to precise dosing of radiation-induced cellular injury and predictable biological responses that can be applied to treat a multitude of central nervous system (CNS) disorders. Herein we review the principles of CNS radiobiology, comparing differences between SRS and conventional radiation therapy. We then review the radiobiology of SRS as it pertains to the treatment of CNS tumors and vascular malformations and the emerging application of SRS for the treatment of functional and psychiatric neurological disorders. Finally, we look toward the future in combining SRS with other novel technologies to improve treatment outcomes for patients with CNS disorders.

Indexed as

arterial venous malformationsconventional radiotherapyCyberknifeDNA damage responsefunctional neurosurgeryGammaknifemetastatic brain tumorsneuro-oncologyneurosurgerypituitary adenomaprimary brain tumorsproton beam radiation therapypsychiatrystereotactic radiosurgery

Identifiers

PMID40563819
PMCPMC12191214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.