Evidence map›Paper›PMID 40563769›Full record

ReviewBrain sciences2025

New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.

Jordan D Gregory, Tenzin Kunkhyen, Sean C Sweat, Jane S Huang, Taryn R Brechbill, Claire E J Cheetham

Abstract readReview
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Reversal of Congenital Hypogonadotropic Hypogonadism.The Journal of clinical endocrinology and metabolism · 2026
    Pooled it
  2. Article
  3. The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan D GregoryDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Tenzin KunkhyenDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Sean C SweatDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-7598-3166
Jane S HuangDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Taryn R BrechbillDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Claire E J CheethamDepartment of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-4038-1501

Funding

Medical Scientist Training ProgramT32GM144300 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICHARD A STEINMAN, Russell S Schwartz · 2022 to 2026
$7.9M
Functional Integration of Newborn Olfactory Sensory Neurons in the Healthy and Regenerating Olfactory SystemR01DC018516 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEETHAM, CLAIRE ELIZABETH JANE · 2021 to 2025
$1.8M
NIDCD NIH HHS R01 DC018516NIDCD NIH HHS R01DC018516NIGMS NIH HHS T32 GM144300
6 · The paper itself

Abstract

The rodent olfactory system is unique in harboring two distinct postnatal neurogenic niches, the olfactory epithelium and the subventricular zone. This results in the ongoing generation of both olfactory sensory neurons (OSNs), which provide odor input to the brain, and multiple molecularly distinct populations of GABAergic interneurons that modulate both input to and output from the olfactory bulb, continuing throughout life for some neuronal types. Here, we review the roles played by these postnatally generated neurons in olfactory processing, plasticity and regeneration. We identify specific roles for individual types of postnatally generated neurons, as well as identifying overarching principles that span multiple neuronal types.

Indexed as

learningolfactory epitheliumpostnatal neurogenesisregenerationsubventricular zone

Identifiers

PMID40563769
PMCPMC12190304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.