Evidence map›Paper›PMID 40563686›Full record

ArticleCancers2025

Redefining the Use of Regorafenib and Trifluridine/Tipiracil Without Bevacizumab in Refractory Metastatic Colorectal Cancer: Findings from the ReTrITA Study.

Carlo Signorelli, Maria Alessandra Calegari, Annunziato Anghelone, Alessandro Passardi, Chiara Gallio, Alessandro Bittoni, Jessica Lucchetti, Lorenzo Angotti, Emanuela Di Giacomo, Ina Valeria Zurlo and 21 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Carlo SignorelliMedical Oncology Unit, S.Rosa Hospital, ASL Viterbo, 01100 Viterbo, Italy.ORCID 0000-0001-9710-4962
Maria Alessandra CalegariOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.
Annunziato AngheloneOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.ORCID 0009-0003-2647-2110
Alessandro PassardiDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-7099-240X
Chiara GallioDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0009-0003-7380-1255
Alessandro BittoniDepartment of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-4056-0067
Jessica LucchettiDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.ORCID 0000-0002-0262-535X
Lorenzo AngottiDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.ORCID 0009-0002-8378-2943
Emanuela Di GiacomoDivision of Medical Oncology, Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.
Ina Valeria ZurloMedical Oncology, "Vito Fazzi" Hospital, 73100 Lecce, Italy.ORCID 0000-0002-8876-4691
Cristina MorelliMedical Oncology Unit, Department of Systems Medicine, Tor Vergata University Hospital, 00133 Rome, Italy.
Emanuela Dell'AquilaIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-7258-1364
Adele ArtemiIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Donatello GemmaMedical Oncology Unit, ASL Frosinone, 03100 Sora, FR, Italy.
Alessandra EmilianiMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, 00186 Rome, Italy.
Marta RibelliMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, 00186 Rome, Italy.
Domenico Cristiano CorsiMedical Oncology, Isola Tiberina Hospital, Gemelli Isola, 00186 Rome, Italy.
Giulia ArriviOncology Unit, Department of Clinical and Molecular Medicine, Sant' Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0003-0541-415X
Federica MazzucaOncology Unit, Department of Clinical and Molecular Medicine, Sant' Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Federica ZorattoUOC Oncologia, Ospedale Santa Maria Goretti, ASL Latina, 04100 Latina, Italy.
Mario Giovanni ChilelliMedical Oncology Unit, S.Rosa Hospital, ASL Viterbo, 01100 Viterbo, Italy.
Marta SchirripaMedical Oncology Unit, S.Rosa Hospital, ASL Viterbo, 01100 Viterbo, Italy.
Francesco SchietromaMedical Oncology Unit, S.Rosa Hospital, ASL Viterbo, 01100 Viterbo, Italy.
Maria Grazia MorandiMedical Oncology Unit, San Camillo de Lellis Hospital, ASL Rieti, 02100 Rieti, Italy.
Fiorenza SantamariaUOC Oncology A, Policlinico Umberto I, 00161 Rome, Italy.ORCID 0000-0002-1214-9342
Manuela DettoriMedical Oncology Department, Ospedale Oncologico Armando Businco, 09121 Cagliari, Italy.
Antonella CosimatiMedical Oncology Department, UO Oncologia Universitaria della Casa della Salute di Aprilia, 04011 Aprilia, LT, Italy.ORCID 0000-0002-2636-3198
Rosa SaltarelliUOC Oncology, San Giovanni Evangelista Hospital, ASL RM5, 00019 Tivoli, RM, Italy.
Alessandro MinelliMedical Oncology Department, UO Oncologia, Ospedale San Paolo, ASL RM4, 00053 Civitavecchia, Italy.
Emanuela Lucci-CordiscoUOC Genetica Medica, Dipartimento di Scienze della Vita e Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.
Michele BassoOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

metastatic colorectal cancerreal-world evidenceregorafenibsequencingsurvivaltoxicitytrifluridine/tipiracil

Identifiers

PMID40563686
PMCPMC12191189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.