Evidence map›Paper›PMID 40563673›Full record

ArticleCancers2025

Integrative Molecular and Immune Profiling in Advanced Unresectable Melanoma: Tumor Microenvironment and Peripheral PD-1+ CD4+ Effector Memory T-Cells as Potential Markers of Response to Immune Checkpoint Inhibitor Therapy.

Manuel Molina-García, María Jesús Rojas-Lechuga, Teresa Torres Moral, Francesca Crespí-Payeras, Jaume Bagué, Judit Mateu, Nikolaos Paschalidis, Vinícius Gonçalves de Souza, Sebastian Podlipnik, Cristina Carrera and 3 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Manuel Molina-GarcíaInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0003-4218-9756
María Jesús Rojas-LechugaOtorhinolaryngology Department, Hospital Clínic de Barcelona, CIBERES, IDIBAPS, Universitat de Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-1402-5167
Teresa Torres MoralInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Francesca Crespí-PayerasInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0009-0009-1754-8375
Jaume BaguéInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0009-0003-6502-5436
Judit MateuInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-0586-1200
Nikolaos PaschalidisBiomedical Research Foundation, Academy of Athens (BRFAA), 4 Soranou Efesiou St., 11527 Athens, Greece.ORCID 0000-0001-6278-4144
Vinícius Gonçalves de SouzaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil.
Sebastian PodlipnikInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0003-4150-0522
Cristina CarreraInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0003-1608-8820
Josep MalvehyInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.
Rui Milton Patricio da Silva-JúniorInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0002-7387-437X
Susana PuigInstitut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain.ORCID 0000-0003-1337-9745

Funding

Instituto de Salud Carlos III PI049494Instituto de Salud Carlos III PI18/00419Instituto de Salud Carlos III PI22/01467"la Caixa" Foundation LCF/PR/SP23/52950009
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

biomarkersCTLA-4gene expression profilingimmune checkpoint inhibitorsimmunophenotypinginterferon-gammamelanomaprogrammed cell death 1 receptorprogression-free survivaltumor microenvironment

Identifiers

PMID40563673
PMCPMC12190280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.