Evidence map›Paper›PMID 40563628›Full record

ArticleCancers2025

Inhibition of PCSK9 Attenuates Liver Endothelial Cell Activation Induced by Colorectal Cancer Stem Cells During Liver Metastasis.

Ander Martin, Daniela Gerovska, Marcos J Arauzo-Bravo, Maitane Duarte García-Escudero, Helena García García, Iratxe Bañares, Naroa Fontal, Geraldine Siegfried, Serge Evrad, Simon Pernot and 2 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. PCSK9 orchestrates the antigen presentation-endothelial barrier axis to potentiate immune exclusion in colorectal cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ander MartinBordeaux Institute of Oncology (BRIC)-UMR1312, University of Bordeaux, 33000 Bordeaux, France.ORCID 0000-0003-4428-0342
Daniela GerovskaComputational Biology and Systems Biomedicine, Biogipuzkoa Health Research Institute, 20014 San Sebastian, Spain.ORCID 0000-0003-0671-4277
Marcos J Arauzo-BravoDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.ORCID 0000-0002-3264-464X
Maitane Duarte García-EscuderoDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.
Helena García GarcíaDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.ORCID 0000-0003-3999-2361
Iratxe BañaresDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.
Naroa FontalDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.
Geraldine SiegfriedBordeaux Institute of Oncology (BRIC)-UMR1312, University of Bordeaux, 33000 Bordeaux, France.
Serge EvradInstitut Bergonié, 33076 Bordeaux, France.ORCID 0000-0003-1063-6822
Simon PernotInstitut Bergonié, 33076 Bordeaux, France.
Abdel-Majid KhatibBordeaux Institute of Oncology (BRIC)-UMR1312, University of Bordeaux, 33000 Bordeaux, France.ORCID 0000-0001-6957-0384
Iker BadiolaDepartment of Cell Biology and Histology, University of the Basque Country, 48940 Leioa, Spain.ORCID 0000-0003-2392-2537

Funding

Basque Government IT1751-22European Union 899417Ministerio de Ciencia, Innovación y Universidades PID2020-119715GB-I00/AEI/10.13039/501100011033University of the Basque Country PIFBUR20/04
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

angiogenesismetastatic nichePCSK9protein convertasetumor microenvironment

Identifiers

PMID40563628
PMCPMC12190733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.