Evidence map›Paper›PMID 40563612›Full record

ArticleCancers2025

DNA Damage Repair Pathway Alterations and Immune Landscape Differences in Pediatric/Adolescent, Young Adult (AYA) and Adult Sarcomas.

Kurt Statz-Geary, Andrew Elliott, Steven Bialick, César Serrano, Margaret von Mehren, Matthew Oberley, Andrea P Espejo-Freire, Priscila Barreto Coelho, Philippos A Costa, Gina Z D'Amato and 6 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. Repurposing public sarcoma multi-omics for neoantigen discovery.Cancer immunology, immunotherapy : CII · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kurt Statz-GearyMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Andrew ElliottCaris Life Sciences, Phoenix, AZ 85040, USA.ORCID 0000-0001-8494-8031
Steven BialickMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-0833-1034
César SerranoVall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.ORCID 0000-0003-1416-8739
Margaret von MehrenFox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0001-6158-890X
Matthew OberleyCaris Life Sciences, Phoenix, AZ 85040, USA.ORCID 0000-0001-6419-2513
Andrea P Espejo-FreireMasonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9903-0864
Priscila Barreto CoelhoMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Philippos A CostaYale Cancer Center/Smilow Cancer Hospital, New Haven, CT 06519, USA.
Gina Z D'AmatoMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-6981-7527
Emily JonczakMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Jonathan C TrentMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-6169-5238
Elizabeth MontgomeryMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-9788-8218
David LombardMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-4292-0185
Andrew RosenbergMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Aditi DhirMiller School of Medicine/Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-9974-0073

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1M
SIRT5 inhibitors and degraders as novel treatments for Ewing sarcomaR01CA253986 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Benner Lombard, NOURI NEAMATI · 2022 to 2026
$2.1M
Carlos III Institute of Health ISCIII PI22-00720CRIS CRIS-excellence2023_44NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA253986NIH HHS 1P30CA240139-20S6NIH HHS 1R01CA253986-24S3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA damage responseprecision medicinesarcoma

Identifiers

PMID40563612
PMCPMC12191036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.