Evidence map›Paper›PMID 40563545›Full record

ArticleBiomolecules2025

Cycloadditions as a Sweet Route to 'Double

Kevin P P Mahoney, Rosemary Lynch, Rhea T Bown, Sunil V Sharma, Piyasiri Chueakwon, G Richard Stephenson, David B Cordes, Alexandra M Z Slawin, Rebecca J M Goss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kevin P P MahoneySchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0009-0006-8360-1857
Rosemary LynchSchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0002-9726-0196
Rhea T BownSchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Sunil V SharmaSchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0002-7833-0144
Piyasiri ChueakwonSchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
G Richard StephensonSchool of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich NR4 7TJ, UK.ORCID 0000-0003-1487-9178
David B CordesSchool of Chemistry, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0002-5366-9168
Alexandra M Z SlawinSchool of Chemistry, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0002-9527-6418
Rebecca J M GossSchool of Chemistry, Integrated Institute of Engineering, and BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/Y513738/1, BB/T017058/1EU Interreg IV Trans Manche/Channel cross-border projects IS:CE chem (ref 4061) and AIcc (ref 4196)European Research Council FP7/2007-2013/ERC agreement no. 614779European Union's Horizon 2020 research and innovation programme 654008
6 · The paper itself

Abstract

Pharmaceuticals, such as the antibiotic erythromycin, and sodium-dependent glucose transporter (SGLT1 & SGTL2) inhibitors such as Bexagliflozin (diabetes) and Sotagliflozin (heart disease), are often sugar-decorated (glycosylated). Glycosylation is a key component of the binding motif in SGLT inhibitors and, in natural products, glycosylation often confers improved bioactivity and bioavailability. Whilst a single

Indexed as

Cycloaddition ReactionGlycosidesGlycosylationGlycosidesbiomimeticcycloadditiongranaticinnatural product analogue

Identifiers

PMID40563545
PMCPMC12190653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.