Evidence map›Paper›PMID 40563518›Full record

ArticleBiomolecules2025

Analysis of Novel DNA Adducts Derived from Acetaldehyde.

Yuuki Betsuyaku, Mina Motohashi, Akira Sassa, Takeji Takamura-Enya, Yukari Totsuka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuuki BetsuyakuDepartment of Chemistry, Kanagawa Institute of Technology, Atsugi-shi, Kanagawa 243-0292, Japan.
Mina MotohashiLaboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Funabashi-shi, Chiba 274-8555, Japan.
Akira SassaGraduate School of Science, Chiba University, Inage-ku, Chiba 263-8522, Japan.ORCID 0000-0003-2454-0223
Takeji Takamura-EnyaDepartment of Chemistry, Kanagawa Institute of Technology, Atsugi-shi, Kanagawa 243-0292, Japan.ORCID 0000-0002-6740-2915
Yukari TotsukaDivision of Carcinogenesis & Prevention, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.ORCID 0000-0003-3221-1796

Funding

Japan Agency for Medical Research and Development 18ck0106264h0002, 20ck0106545h0001, 22jk0210009h0001, 23ck0106800h0001, 24ck0106800h0002, 25ck0106800h0003, 24ck0106944h0001National Cancer Center Research and Development Fund 2023-A-5
6 · The paper itself

Abstract

Alcohol consumption is a known risk factor for esophageal and liver cancers. Recently, it was reported that mutation signatures characterized by T:A to C:G mutations (SBS16), which are suggested to be associated with alcohol intake, are frequently detected in esophageal, liver, and stomach cancers among the Japanese population. However, the scientific evidence linking alcohol consumption to SBS16 remains lacking. Acetaldehyde (AA), a carcinogenic metabolite of alcohol, is considered a key contributor to alcohol-related cancer development. Although the guanine adducts associated with alcohol exposure have been reported as part of its carcinogenic mechanism, an adenine adduct,

Indexed as

AcetaldehydeDNA AdductsAnimalsHumansMaleMiceMutationAcetaldehydeDNA AdductsacetaldehydeDNA adductomemutation signatureN1-oxydiethylidene-dAN6-ethyl-dASBS16

Identifiers

PMID40563518
PMCPMC12190651

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.