Evidence map›Paper›PMID 40563475›Full record

ArticleBiomolecules2025

Unraveling the Multi-Omic Landscape of Extracellular Vesicles in Human Seminal Plasma.

Laura Governini, Alesandro Haxhiu, Enxhi Shaba, Lorenza Vantaggiato, Alessia Mori, Marco Bruttini, Francesca Loria, Natasa Zarovni, Paola Piomboni, Claudia Landi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Extracellular vesicles: key mediators inFrontiers in veterinary science · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura GoverniniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-5610-9548
Alesandro HaxhiuDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6208-0358
Enxhi ShabaFunctional Proteomics Lab, Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9561-2426
Lorenza VantaggiatoFunctional Proteomics Lab, Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-4078-7250
Alessia MoriTuscany Centre for Precision Medicine (CReMeP), Department of Medicine Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.
Marco BruttiniTuscany Centre for Precision Medicine (CReMeP), Department of Medicine Surgery and Neurosciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-1063-2522
Francesca LoriaHansaBioMed Life Sciences Ltd., 12618 Tallinn, Estonia.ORCID 0000-0003-1180-4883
Natasa ZarovniHansaBioMed Life Sciences Ltd., 12618 Tallinn, Estonia.ORCID 0000-0003-2983-7886
Paola PiomboniDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2987-7028
Claudia LandiFunctional Proteomics Lab, Department of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-0410-8038
Alice LuddiDepartment of Molecular and Developmental Medicine, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4946-7336

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular Vesicles (EVs) from seminal plasma have achieved attention due to their potential physiopathological role in male reproductive systems. This study employed a comprehensive proteomic and transcriptomic approach to investigate the composition and molecular signatures of EVs isolated from human seminal plasma. EVs from Normozoospermic (NORMO), OligoAsthenoTeratozoospermic (OAT), and Azoospermic (AZO) subjects were isolated using a modified polymer precipitation-based protocol and characterized for size and morphology. Comprehensive proteomic analysis, using both gel-free and gel-based approaches, revealed distinct protein profiles in each group (

Indexed as

Extracellular VesiclesSemenAdultAzoospermiaGene Expression ProfilingHumansMaleMultiomicsProteomeProteomicsSpermatogenesisTranscriptomeProteomeextracellular vesiclesintercellular communicationmale reproductive tractproteomicsreproductionseminal plasmatranscriptomics

Identifiers

PMID40563475
PMCPMC12190863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.